The Dual Action of Human Antibodies Specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites
G. E. Weiss, R. J. Ragotte, D. Quinkert, A. M. Lias, M. G. Dans, C. Boulet, B. G. Williams, B. S. Crabb, S. J. Draper, P. R. Gilson
This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.
bioRxiv · Feb 7, 2023 · PreprintMicrobiology