Author

T. F. de Koning-Ward

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:plant (other)· 3 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

B. E. Sleebs· 2 shared D. J. Creek· 2 shared G. Siddiqui· 2 shared M. G. Dans· 2 shared N. A. Counihan· 2 shared P. R. Gilson· 2 shared S. McGowan· 2 shared T. R. Malcolm· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

B. E. Sleebs

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 2, 2023

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

M. G. Dans, C. Boulet, G. M. Watson…·P. R. Gilson

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

DOI 10.1101/2023.11.02.565411

plant (other)experimental assay

𝕏 PostBluesky

MicrobiologybioRxivOct 1, 2023

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

R. C. Edgar, G. Siddiqui, T. R. Malcolm…·S. McGowan

This paper identifies MMV1557817 as a dual aminopeptidase inhibitor effective against multiple Plasmodium species and highlights its potential as a multi-target antimalarial drug.

DOI 10.1128/mbio.00966-24

plant (other)experimental assay

𝕏 PostBluesky

MicrobiologybioRxivNov 23, 2021

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

R. C. S. Edgar, G. Siddiqui, K. Hjerrild…·T. F. De Koning-Ward

This study validates PfA-M17 as a novel drug target by showing its essential role in Plasmodium falciparum survival and demonstrating the efficacy of a specific inhibitor.

DOI 10.7554/elife.80813

plant (other)experimental assay

𝕏 PostBluesky

Cell BiologybioRxivSep 13, 2019

Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

M. G. Dans, G. E. Weiss, D. W. Wilson…·P. R. Gilson

The paper screens a compound library to identify inhibitors of Plasmodium falciparum egress and invasion, finding several compounds with specific inhibitory effects.

DOI 10.1016/j.ijpara.2020.01.002

humanproteomics

𝕏 PostBluesky