G. Grenci

Fast volumetric fluorescence lifetime imaging of multicellular systems using single-objective light-sheet microscopy

This paper accelerates fluorescence lifetime imaging (FLIM) using single-objective light-sheet microscopy, achieving faster and less phototoxic imaging of live multicellular systems.

Cortical ductility governs cell-cell adhesion mechanics

This study introduces a new method to measure energy dissipation during cell-cell junction rupture and shows that cortical tension and shape relaxation time determine whether junctions behave ductile or brittle.

Digitalized organoids: integrated pipeline for 3D high-speed analysis of organoid structures using multilevel segmentation and cellular topology

This paper introduces a pipeline for 3D organoid analysis using multilevel segmentation and cellular topology to quantify morphology and topology changes under various stress conditions.

Migrating neurons adapt motility modes to brain microenvironments via a mechanosensor, PIEZO1

The paper shows cerebellar granule neurons switch migratory modes in 3D environments using PIEZO1 to generate contractile forces.

Bioengineering a Miniaturized In Vitro 3D Myotube Contraction Monitoring Chip For Modelization of Muscular Dystrophies

This paper develops a miniaturized 3D myotube contraction monitoring chip to model muscular dystrophies, showing contractile dysfunction in L-CMD mutant myotubes with reduced starting material requirements.

High content 3D imaging method for quantitative characterization of organoid development and phenotype.

The paper introduces a high-content 3D imaging platform for organoid development analysis, enabling automated, high-throughput imaging and AI-based quantification of morphological features across multiple scales.

Forces and constraints controlling podosome assembly and disassembly

This study investigates how mechanical forces and membrane tension affect podosome assembly and disassembly in cells.