H. T. Ong

E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and collective migration modes.

Digitalized organoids: integrated pipeline for 3D high-speed analysis of organoid structures using multilevel segmentation and cellular topology

This paper introduces a pipeline for 3D organoid analysis using multilevel segmentation and cellular topology to quantify morphology and topology changes under various stress conditions.

Actin polymerization and crosslinking drive left-right asymmetry in single cell and cell collectives

The paper identifies actin polymerization regulators that drive chiral actin swirling and left-right asymmetry in single cells and cell collectives.

High content 3D imaging method for quantitative characterization of organoid development and phenotype.

The paper introduces a high-content 3D imaging platform for organoid development analysis, enabling automated, high-throughput imaging and AI-based quantification of morphological features across multiple scales.

Mechanical Roles of Vinculin/β-catenin interaction in Adherens Junction

The paper investigates the mechanical role of vinculin/β-catenin interaction in adherens junctions, showing that vinculin forms a direct structural connection with β-catenin to support mechanical tension and stabilize complexes.

Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

The paper develops a single-cell assay to analyze EphA receptor clustering in cancer cells, revealing its persistence through division and association with migration and drug resistance.

Force dependence of filopodia adhesion: involvement of myosin II and formins

This study investigates how forces affect filopodia adhesion, showing that myosin IIA and formins are essential for force-dependent adhesion and substrate preference.