G. Kaber

Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes

This study shows that inhibiting hyaluronan synthesis with 4-MU prevents β-cell loss in obesity-associated type 2 diabetes by increasing survivin expression and blocking apoptosis.

FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues

The paper shows FOXP3+ Treg use heparanase to access IL-2 bound to ECM in inflamed tissues, enhancing their function and stability.

Pf Bacteriophage Inhibits Neutrophil Migration in the Lung

The paper shows that Pf4 phage inhibits neutrophil migration in the lung by reducing CXCL5 production during bacterial infection.

A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells

This study investigates how cystic fibrosis basal airway epithelial cells respond to the filamentous phage Pf4 and LPS, showing antiviral responses and altered immune signaling.

The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice

This paper investigates the pharmacokinetics and pharmacodynamics of 4-MU and its metabolite 4-MUG in mice, showing significant differences in exposure and bioavailability between administration routes.

The circulating phageome reflects bacterial infections

The paper shows that circulating phageome in cfDNA reflects bacterial infections and can distinguish between pathogenic and contaminant bacteria.

Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection

This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.

Sustained Release of IL-2 Using an Injectable Hydrogel Prevents Autoimmune Diabetes

This paper develops an IL-2 hydrogel that prevents diabetes in NOD mice by sustained release and immune modulation.

Filamentous Bacteriophage Delay Healing of Pseudomonas-Infected Wounds

This study shows filamentous bacteriophage delays wound healing in Pseudomonas aeruginosa infections by inhibiting keratinocyte migration, supported by a patient cohort study.