Author

N. L. Haddock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

P. L. Bollyky· 4 shared A. Hargil· 3 shared G. Kaber· 3 shared E. B. Burgener· 2 shared J. D. Pourtois· 2 shared L. J. Barkal· 2 shared M. J. Kratochvil· 2 shared P. Bollyky· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

P. L. Bollyky

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Rapid assessment of changes in phage bioactivity using dynamic light scattering

T. Dharmaraj, M. J. Kratochvil, J. D. Pourtois, Q. Chen, M. Hajfathalian, A. Hargil, Y.-H. Lin, Z. R. Evans, A. Oromi-Bosch, J. D. Berry, R. McBride, N. L. Haddock, D. R. Holman, J. D. Van Belleghem, T. H. Chang, , P. L. Bollyky

This paper uses Dynamic Light Scattering to assess phage bioactivity changes over time and optimize storage conditions for clinical phage applications.

bioRxiv · Jul 2, 2023Biophysics

Bacteriophage populations mirror those of bacterial pathogens at sites of infection

N. L. Haddock, L. J. Barkal, P. L. Bollyky

The paper analyzes cell-free DNA from infected bodily fluids to show that bacteriophage sequences mirror the abundance of their bacterial hosts at infection sites.

bioRxiv · May 17, 2023Microbiology

A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells

M. C. Popescu, N. L. Haddock, E. B. Burgener, L. S. Rojas-Hernandez, G. Kaber, A. Hargil, P. Bollyky, C. E. Milla

This study investigates how cystic fibrosis basal airway epithelial cells respond to the filamentous phage Pf4 and LPS, showing antiviral responses and altered immune signaling.

bioRxiv · Sep 27, 2022 · PreprintCell Biology

The circulating phageome reflects bacterial infections

N. L. Haddock, L. J. Barkal, N. Ram-Mohan, G. Kaber, C. Y. Chiu, A. S. Bhatt, S. Yang, P. Bollyky

The paper shows that circulating phageome in cfDNA reflects bacterial infections and can distinguish between pathogenic and contaminant bacteria.

bioRxiv · Aug 15, 2022 · PreprintMicrobiology

The Impact of Pf Bacteriophages on the Fitness of Pseudomonas aeruginosa; A Mathematical Modeling Approach

J. D. Pourtois, M. J. Kratochvil, Q. Chen, N. L. Haddock, E. B. Burgener, G. A. De Leo, P. L. Bollyky

This paper uses a mathematical model to show that Pf+ Pseudomonas aeruginosa strains can outcompete Pf- strains under specific antibiotic conditions, promoting antibiotic tolerance.

bioRxiv · Aug 30, 2020 · PreprintMicrobiology

Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection

P. L. Marshall, N. Nagy, G. Kaber, G. L. Barlow, A. Ramesh, B. J. Xie, M. H. Linde, N. L. Haddock, C. A. Lester, Q.-L. Tran, C. R. de Vries, A. Malkovskiy, I. Gurevich, H. Martinez, H. F. Kuipers, , P. L. Bollyky

This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.

bioRxiv · Aug 28, 2020Immunology