A. Palma

Salmonella SiiE-mediated apical invasion into colonocytes depends on MUC1 α2,3-linked sialic acids

This study shows Salmonella uses 2,3-sialylated MUC1 on colonocytes for apical invasion, identified through glycan analysis and ex vivo models.

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency

This study identifies CHK2's role in regulating MUS81-dependent DSBs during replication stress and BRCA2 deficiency by phosphorylating MUS81.

A new insight into MYC action: control of RNA polymerase II methylation and transcription termination

This study shows MYC regulates RNA polymerase II methylation and transcription termination through interaction with PRMT5, and its inhibition affects gene expression in cancer cells.

Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA Vaccination

The paper compares antibody reactivity patterns between natural SARS-CoV-2 infection and mRNA vaccination, finding that vaccination induces stronger and broader antibody responses, including cross-reactivity against SARS antigens.

SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors

The paper investigates micro-heterogeneity in dystrophic fibro/adipogenic progenitors (FAPs) using SCA-1 expression levels and shows differential adipogenic and fibrogenic responses between two FAP states.

Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum.

This study identifies F&H peptide-containing proteins that interact with OCRL/Dd5P4 in Dictyostelium discoideum, revealing their role in endocytic membrane cycling and potential involvement in Lowe Syndrome phenotypes.

Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors

This study identifies glucocorticoids as both inhibitors and promoters of muscle fibro/adipogenic progenitor differentiation, revealing their dual role in muscle homeostasis.

RAD51 AND MITOTIC FUNCTION OF MUS81 ARE ESSENTIAL FOR RECOVERY FROM LOW-DOSE OF CAMPTOTHECIN IN THE ABSENCE OF THE WRN EXONUCLEASE

The paper investigates how WRN exonuclease deficiency affects replication fork recovery from camptothecin, showing RAD51 and MUS81 mitotic function are essential to prevent genome instability.

Phosphorylation By CK2 Regulates MUS81/EME1 In Mitosis And After Replication Stress

This study shows CK2 phosphorylates MUS81 at Serine 87 in mitosis and under replication stress, promoting its interaction with SLX4 and affecting chromosome stability.