Author

G. M. Stott

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. R. Frank· 1 shared D. G. McFadden· 1 shared J. Kim· 1 shared L. Neckers· 1 shared N. S. Williams· 1 shared P. Mishra· 1 shared S. D. Shelton· 1 shared V. Li· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. R. Frank

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1 paper

Recent·Most cited

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

A. R. Frank, V. Li, S. D. Shelton, J. Kim, G. M. Stott, L. Neckers, Y. Xie, N. S. Williams, P. Mishra, D. G. McFadden

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

bioRxiv · Aug 16, 2022Cancer Biology