Author

A. R. Frank

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. G. McFadden· 2 shared A. D. McNaughton· 1 shared A. J. Wilson· 1 shared D. Herrera· 1 shared E. M. Van Fossen· 1 shared F. Vandiver· 1 shared G. M. Stott· 1 shared J. Kim· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

D. G. McFadden

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Author profile →

3 papers

Recent·Most cited

Forward genetic screens identify mechanisms of resistance to small molecule lactate dehydrogenase inhibitors

A. R. Frank, F. Vandiver, D. G. McFadden

This study identifies two resistance mechanisms to LDH inhibitors in complex I-mutant HTC models through forward genetic screens.

bioRxiv · Sep 30, 2023Cancer Biology

Profiling sorghum-microbe interactions with a specialized photoaffinity probe identifies key sorgoleone binders in Acinetobacter pittii

J. O. Kroll, E. M. Van Fossen, L. N. Anderson, A. D. McNaughton, D. Herrera, Y. Oda, A. J. Wilson, W. C. Nelson, N. Kumar, A. R. Frank, J. R. Elmore, P. Handakumbura, V. S. Lin, R. G. Egbert

This paper uses a sorgoleone-based photoaffinity probe to identify proteins in Acinetobacter pittii that bind sorgoleone, revealing potential pathways for microbial interaction with this plant metabolite.

bioRxiv · May 31, 2023Biochemistry

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

A. R. Frank, V. Li, S. D. Shelton, J. Kim, G. M. Stott, L. Neckers, Y. Xie, N. S. Williams, P. Mishra, D. G. McFadden

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

bioRxiv · Aug 16, 2022Cancer Biology