Author

S. Z. Xie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:human· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:multiome· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

A. Murison· 5 shared J. E. Dick· 5 shared A. G. X. Zeng· 3 shared E. Flores-Figueroa· 3 shared L. Garcia-Prat· 3 shared A. G. Aguilar-Navarro· 2 shared D. Parris· 2 shared E. Wagenblast· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersCell Biology

A. Murison

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

E. Lettera, S. Scala, L. Basso-Ricci, T. Tavella, L. della Volpe, E. Lofurno, K. Kauffmann, L. Garcia-Prat, P. Quaranta, R. Hernandez, A. Murison, K. Giannetti, A. Aguilar-Navarro, S. Beretta, A. Conti, , R. Di Micco

The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.

bioRxiv · Sep 15, 2023 · PreprintCell Biology

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

N. A. Jakobsen, S. Turkalj, A. G. X. Zeng, B. Stoilova, M. Metzner, M. S. Nagree, S. Shah, R. Moore, B. Usukhbayar, M. A. Salazar, G.-A. Gafencu, A. Kennedy, S. Newman, B. J. L. Kendrick, A. H. Taylor, , P. Vyas

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

bioRxiv · Sep 12, 2023 · PreprintCancer Biology

Identification of a human hematopoietic stem cell subset that retains memory of inflammatory stress

A. G. X. Zeng, M. S. Nagree, N. A. Jakobsen, S. Shah, A. Murison, J.-G. Cheong, S. Turkalj, I. Lim, L. Jin, J. Araujo, A. G. Aguilar-Navarro, D. Parris, J. McLeod, H. Kim, H. S. Lee, , S. Z. Xie

The paper identifies a human HSC subset with inflammatory memory that accumulates with age and clonal hematopoiesis, potentially increasing cancer and infection risks.

bioRxiv · Sep 11, 2023 · PreprintCell Biology

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing

T. Itkin, S. Houghton, R. Schreiner, Y. Lin, C. Badwe, V. Voisin, A. Murison, N. Seyedhassantehrani, K. B. Kaufmann, L. Garcia-Prat, G. T. Booth, F. Geng, Y. Liu, J. M. Gomez-Salinero, J.-H. Shieh, , S. Rafii

The paper identifies Fli-1's role in regulating HSC activation during regenerative hematopoiesis by enabling niche signaling and functional recovery.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

J. F. Woolley, K. Chen, G. T. Saffi, G. E. Genc, D. K. C. Lee, I. Dzneladze, R. He, J. T.-S. Chow, M. M. Gabra, M. H. Son, C. M. P. Melo, C. A. Newell, A. He, E. M. Schoof, S. Z. Xie, , L. Salmena

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

bioRxiv · Mar 25, 2021 · PreprintCancer Biology

Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

L. Garcia-Prat, K. B. Kaufmann, F. Schneiter, V. Voisin, A. Murison, J. Chen, M. Chan-Seng-Yue, O. I. Gan, J. L. McLeod, S. A. Smith, M. C. Shoong, D. Parris, K. Pan, A. G. X. Zeng, G. Krivdova, , J. E. Dick

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

bioRxiv · Feb 24, 2021 · PreprintCell Biology