Author

D. K. C. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Salmena· 2 shared R. J. Botelho· 2 shared A. He· 1 shared A. Rashid· 1 shared C. A. Newell· 1 shared C. Camardi· 1 shared C. J. Guidos· 1 shared C. M. P. Melo· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

L. Salmena

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Author profile →

2 papers

Recent·Most cited

The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling

V. Chan, C. Camardi, K. Zhang, L. Orofiamma, K. E. Anderson, J. Hoque, L. Bone, Y. Awadeh, D. K. C. Lee, N. J. Fu, J. T. S. Chow, L. Salmena, L. R. Stephens, P. T. Hawkins, C. N. Antonescu, R. J. Botelho

This study shows that LCLAT1 is required for EGF-mediated PtdIns(3,4,5)P3 generation and Akt signaling in cancer and retinal cells.

bioRxiv · Jan 26, 2023Cell Biology

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

J. F. Woolley, K. Chen, G. T. Saffi, G. E. Genc, D. K. C. Lee, I. Dzneladze, R. He, J. T.-S. Chow, M. M. Gabra, M. H. Son, C. M. P. Melo, C. A. Newell, A. He, E. M. Schoof, S. Z. Xie, , L. Salmena

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

bioRxiv · Mar 25, 2021 · PreprintCancer Biology