Author

G.-P. Dotto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

L. Mazzeo· 3 shared M. Ma· 3 shared S. Ghosh· 3 shared A. Samarkina· 2 shared M. P. Levesque· 2 shared A. Clocchiatti· 1 shared A. Katarkar· 1 shared A. P. Bowman· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

L. Mazzeo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation.

S. Ghosh, J. Isma, L. Mazzeo, A. Toniolo, C. Simon, G.-P. Dotto

This study shows that loss of androgen receptor increases lamin A/C phosphorylation, driving cancer-associated fibroblast activation through transcriptional changes.

bioRxiv · Jun 28, 2023 · PreprintCancer Biology

Androgen Receptor is a Determinant of Melanoma Targeted Drug Resistance

A. Samarkina, M. K. Youssef, P. Ostano, S. Ghosh, M. Ma, B. Tassone, T. Proust, G. Chiorino, M. P. Levesque, G.-P. Dotto

This study shows that androgen receptor activity contributes to melanoma resistance to BRAF/MEK inhibitors and suggests targeting AR could improve treatment outcomes.

bioRxiv · May 27, 2022Cancer Biology

Sphingolipid Control of Fibroblast Heterogeneity Revealed by Single-Cell Lipidomics

L. Capolupo, I. Khven, L. Mazzeo, G. Glousker, F. Russo, J. Paz Montoya, S. Ho, D. R. Bhandari, A. P. Bowman, S. Ellis, R. Guiet, J. Muthing, B. Spengler, R. M. A. Heeren, G.-P. Dotto, , G. D'Angelo

This study identifies sphingolipid composition as a driver of fibroblast heterogeneity and state transitions using single-cell lipidomics and transcriptomics.

bioRxiv · Feb 23, 2021 · PreprintBiochemistry

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis

M. Ma, S. Ghosh, D. Tavernari, A. Katarkar, A. Clocchiatti, L. Mazzeo, A. Samarkina, J. Epiney, Y.-R. Yu, P.-C. Ho, M. P. Levesque, B. Özdemir, G. Ciriello, R. Dumme, G.-P. Dotto

This study shows that androgen receptor signaling promotes melanoma cell growth and tumorigenesis, with AR inhibition reducing proliferation, enhancing DNA repair, and inducing immune responses.

bioRxiv · May 26, 2020Cancer Biology

Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors

M. Ma, P. Bordignon, G.-P. Dotto, S. Pelet

The paper develops a synthetic fluorescent biosensor to monitor MAPK activity dynamics in live cells, showing improved sensitivity and applicability across multiple cell types and conditions.

bioRxiv · Sep 8, 2019Cell Biology