Author

George Pengo

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Ivana SemovaiD· 1 shared Joanna KrawczykiD· 1 shared Kiran J. Biddinger· 1 shared Krishna G. AragamiD· 1 shared Linus T.-Y. TsaiiD· 1 shared Marcia C. HaigisiD· 1 shared Mareike SchelliD· 1 shared Matt KankeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Ivana SemovaORCID

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1 paper

Recent·Most cited

The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

Joanna Krawczyk, William O’Connor, Pedro Henrique Vendramini, Mareike Schell, Kiran J. Biddinger, Matt Kanke, George Pengo, Ivana Semova, Tiffany Fougeray, Marcia C. Haigis, Krishna G. Aragam, Wouter H. Lamers, Linus T.-Y. Tsai, Praveen Sethupathy, Sudha B. Biddinger

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

Molecular Metabolism · Jul 16, 2025Peer-reviewedPhysiology