Linus T.-Y. Tsai

Single-Nuclear RNA Sequencing Reveals Regional Specialization and Cellular Interactions in Epicardial and Perivascular Adipose Tissue

This study uses snRNA-seq to analyze human adipose tissue depots, identifying distinct adipocyte and progenitor subpopulations and depot-specific intercellular communication networks, with changes observed in disease states.

Rapid Remodeling of Human White Adipose Tissue Following Bariatric Surgery

This study identifies rapid remodeling of human subcutaneous white adipose tissue within one month after bariatric surgery using snRNA-seq, revealing changes in adipocyte populations and transcriptional dynamics.

The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population

The paper uses single-nuclear RNA sequencing to analyze adipose tissue in lymphedema patients, identifying a stromal cell population that promotes lymphangiogenesis.

A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution

This study creates a spatially-resolved transcriptional atlas of the murine dorsal pons using snRNA-seq and MERFISH, identifying 120 neuronal subtypes and their spatial distribution.

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

This study shows aging impairs beige adipogenesis and adipocyte metabolic responses to cold, identifies Npr3 as a marker gene, and provides insights into age-related adipose tissue dysfunction.

Mesothelial cells are not a source of adipocytes in mice

This study shows that mesothelial cells are not a source of visceral adipocytes in mice, challenging a recent paradigm based on Wt1 lineage tracing.

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

Multi-trait genome-wide association meta-analysis of dietary intake identifies new loci and genetic and functional links with metabolic traits

This study identifies 96 genome-wide significant loci associated with dietary intake variation using a multi-trait GWAS meta-analysis across 283,119 individuals.