Author

Kiran J. Biddinger

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetic & Genomic Medicine· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Krishna G. AragamiD· 2 shared Abirami VeluchamyiD· 1 shared Akshay ShekhariD· 1 shared Albert HenryiD· 1 shared Alex S. F. DoneyiD· 1 shared Ana Maria ValdesiD· 1 shared Andrew D. MorrisiD· 1 shared Andrew P. MorrisiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Krishna G. AragamORCID

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2 papers

Recent·Most cited

The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

Joanna Krawczyk, William O’Connor, Pedro Henrique Vendramini, Mareike Schell, Kiran J. Biddinger, Matt Kanke, George Pengo, Ivana Semova, Tiffany Fougeray, Marcia C. Haigis, Krishna G. Aragam, Wouter H. Lamers, Linus T.-Y. Tsai, Praveen Sethupathy, Sudha B. Biddinger

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

Molecular Metabolism · Jul 16, 2025Peer-reviewedPhysiology

Genome-wide association analysis reveals insights into the molecular aetiology underlying dilated cardiomyopathy

Sean Lee Zheng, Albert Henry, Douglas Ewan Cannie, Michael Lee, David Miller, Kathryn A. McGurk, Isabelle Bond, Xiao Yun Xu, Hanane G. Issa, Catherine Francis, Antonio de Marvao, Pantazis I. Theotokis, Rachel J. Buchan, Doug Speed, Erik Abner, , Patrick T. Ellinor

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

Nature Genetics · Nov 21, 2024Peer-reviewedGenetic & Genomic Medicine