Author

Yuna Hirohashi

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alan D. D’AndreaiD· 2 shared Eliezer M. Van AlleniD· 2 shared Geoffrey Ira ShapiroiD· 2 shared Shuhei AsadaiD· 2 shared Sirisha MukkavalliiD· 2 shared Adam S. KibeliD· 1 shared Amanda GarzaiD· 1 shared Avneesh SaravanapavaniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Alan D. D’AndreaORCID

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Author profile →

3 papers

Recent·Most cited

Tumor-myeloid crosstalk drives therapy resistance in localized bladder cancer

Filipe L.F. Carvalho, Ji‐Hyun Lee, Nikolaos Kalavros, Yuzhen Zhou, Daniel E. Michaud, Isabella Stelter, Hiba Siddiqui, Konrad Stawiski, Ramya Ravindranathan, Julia Perera, Shuoshuo Wang, Breanna M. Titchen, Amanda Garza, Kevin Bi, Jihye Park, , Eliezer M. Van Allen

This study identifies tumor-myeloid crosstalk as a driver of cisplatin resistance in bladder cancer and proposes PARP14 inhibition as a therapeutic strategy.

Cell Press Blue · Aug 20, 2026Peer-reviewedCancer Biology

Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors

Guang‐Li Zhu, Shuhei Asada, Huy Q. Nguyen, Yuna Hirohashi, Lifang Sun, Avneesh Saravanapavan, Erfan Rahmani, Maryia Hrynashka, Sirisha Mukkavalli, Mona Batish, Geoffrey Ira Shapiro, Alan D. D’Andrea

This study identifies a defect in MMEJ repair in SMARCB1-deficient tumors, leading to hyper-dependence on the FA/BRCA pathway, which can be targeted for therapy.

Science Advances · Aug 14, 2026Peer-reviewedCancer Biology

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Shuhei Asada, Guangli Zhu, Jithma P. Abeykoon, Yutaro Tanaka, Huy Nguyen, Yuna Hirohashi, Divya Iyer, Nicholas William Ashton, Sirisha Mukkavalli, Martha Velazquez, Lige Jiang, Miles D. Del Busso, Judith Jebastin Thangaiah, Steven Ian Robinson, Kalindi Parmar, , Alan D. D’Andrea

This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.

Molecular Cell · Jul 21, 2026Peer-reviewedCancer Biology