Author

H. Adler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. Hales· 4 shared E. Mitsi· 4 shared H. Hill· 4 shared J. Reine· 4 shared J. Rylance· 4 shared S. Pojar· 4 shared V. Connor· 4 shared C. Solorzano· 3 shared

Activity by Year

2018-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

C. Hales

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment

T. Günther, J. Fröhlich, L. Burkhardt, C. Herrde, S. Ohno, H. Adler, A. Grundhoff

This study compares the epigenetic features of KSHV and MHV-68, showing that KSHV rapidly recruits polycomb repressive complexes through specific cis-acting sequence features, unlike MHV-68.

bioRxiv · May 15, 2019Microbiology

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

J. Reine, B. F. Carniel, C. Solorzano, E. Mitsi, S. Pojar, E. Nikolau, E. L. German, A. D. Hyder-Wright, H. Hill, C. Hales, L. Brown, V. Horsley, L. Hughes, S. Zaidi, V. Connor, , S. P. Jochems

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

bioRxiv · Mar 14, 2019 · PreprintImmunology

Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization

E. Nikolaou, S. P. Jochems, E. Mitsi, S. Pojar, E. Negera, J. Reine, B. Carniel, A. Soares-Schanoski, V. Connor, H. Adler, S. R. Zaidi, C. Hales, H. Hill, A. Hyder-Wright, S. B. Gordon, , D. Ferreira

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.

bioRxiv · Nov 5, 2018 · PreprintImmunology

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

S. P. Jochems, F. Marcon, B. F. Carniel, M. Holloway, E. Mitsi, E. Smith, J. F. Gritzfeld, C. Solorzano, J. Reine, S. Pojar, E. Nikolaou, E. L. German, A. Hyder-Wright, H. Hill, C. Hales, , D. M. Ferreira

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.

bioRxiv · Jun 20, 2018Immunology

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

J. Rylance, W. A. de Steenhuijsen Piters, S. Pojar, E. Nikolaou, E. German, E. Mitsi, S. Jochems, B. Carniel, C. Solorzano, J. Reine, J. Gritzfeld, M. L. J. Chu, K. Arp, A. D. Hyder-Wright, H. Hill, , D. M. Ferreira

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.

bioRxiv · Jun 14, 2018Immunology