Author

L. Spiga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:bacteria (other)· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

W. Zhu· 4 shared M. G. Winter· 3 shared F. Faber· 2 shared H. D. Williams· 2 shared H. L. Andrews-Polymenis· 2 shared S. E. Winter· 2 shared A. Filloux· 1 shared A. J. Westermann· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersMicrobiology

W. Zhu

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Gene regulation of infection-associated L-tartrate metabolism in Salmonella enterica serovar Typhimurium

V. K. Rojas, M. G. Winter, A. Jimenez Lopez, N. W. Tanner, S. L. Crockett, L. Spiga, D. R. Hendrixson, S. E. Winter

This paper investigates how Salmonella regulates L-tartrate metabolism during infection by integrating substrate availability and electron acceptor cues.

bioRxiv · Feb 5, 2024 · PreprintMicrobiology

The RNA-binding protein RbpB is a central regulator of polysaccharide utilization in gut Bacteroides

A.-S. Ruttiger, D. Ryan, L. Spiga, V. Lamm-Schmidt, G. Prezza, S. Reichardt, L. Barquist, F. Faber, W. Zhu, A. J. Westermann

This study identifies RbpB as a key RNA-binding protein regulating polysaccharide utilization in gut Bacteroides through post-transcriptional control of PULs.

bioRxiv · Dec 22, 2023 · PreprintMicrobiology

Byproducts of inflammatory radical metabolism provide transient nutrient niches for microbes in the inflamed gut

L. Spiga, M. G. Winter, M. Muramatsu, V. Rojas, R. Chanin, W. Zhu, E. R. Hughes, S. Taylor, F. Faber, S. Porwollik, T. Carvalho, T. Qin, R. Santos, H. L. Andrews-Polymenis, M. McClelland, S. E. Winter

The paper investigates how inflammatory radicals generate tartaric acid isomers, which serve as transient nutrients for gut pathogens in murine models.

bioRxiv · Dec 8, 2023 · PreprintMicrobiology

Laser Desorption Rapid Evaporative Ionisation Mass Spectrometry (LD-REIMS) demonstrates a direct impact of hypochlorous acid stress on PQS-mediated quorum sensing in Pseudomonas aeruginosa

R. Bradley, D. Simon, L. Spiga, Y. Xiang, Z. Takats, H. D. Williams

This paper uses LD-REIMS to show HOCl stress reduces PQS quorum sensing and virulence factors in P. aeruginosa.

bioRxiv · Oct 11, 2023 · PreprintMicrobiology

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

L. Spiga, R. T. Fansler, Y. R. Perera, N. G. Shealy, M. J. Munneke, T. P. Torres, H. David, A. Lemoff, X. Ran, K. L. Richardson, N. Pudlo, E. C. Martens, Z. J. Yang, E. P. Skaar, M. X. Byndloss, , W. Zhu

This study shows that the commensal bacterium Bacteroides thetaiotaomicron acquires iron using siderophores from Salmonella, evading host sequestration by lipocalin-2 and allowing Salmonella to bypass nutritional immunity.

bioRxiv · Jun 25, 2023 · PreprintMicrobiology

Taxonomic and metagenomic analyses define the development of the microbiota in the chick

L. M. Bogomolnaya, M. Talamantes, J. Rocha, A. Nagarajan, W. Zhu, L. Spiga, M. G. Winter, K. Konganti, L. G. Adams, S. Winter, H. L. Andrews-Polymenis

This paper tracks microbiota development in chicks using taxonomic and metagenomic analyses, showing pathogen-induced changes and identifying amino acid biosynthesis as critical for Salmonella colonization.

bioRxiv · Aug 30, 2022Microbiology

Novel structural components generate distinct type VI secretion system anchoring modes

P. Bernal, R. C. D. Furniss, S. Fecht, R. C. Y. Leung, L. Spiga, D. A. I. Mavridou, A. Filloux

The paper identifies novel structural components that stabilize short TssA-containing T6SSs, leading to distinct firing behaviors and aggression strategies in bacteria.

bioRxiv · Apr 29, 2020Microbiology

Response of Pseudomonas aeruginosa to the innate immune system-derived oxidants hypochlorous acid and hypothiocyanous acid

K. V. Farrant, L. Spiga, J. C. Davies, H. D. Williams

This study identifies RclR as a key regulator of Pseudomonas aeruginosa's response to HOCl and HOSCN, revealing its role in upregulating stress response genes and coordinating survival mechanisms.

bioRxiv · Jan 9, 2020Microbiology