Author

H. E. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1

Frequent Co-Authors

J. A. Alspaugh· 2 shared A. J. Crossen· 1 shared C. L. Telzrow· 1 shared C. M. Fernandes· 1 shared D. A. V. Blanco· 1 shared J. L. Reedy· 1 shared J. M. Vyas· 1 shared J. W. Saelens· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

J. A. Alspaugh

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The C-type Lectin Receptor Dectin-2 is a receptor for Aspergillus fumigatus galactomannan

J. L. Reedy, A. J. Crossen, P. E. Negoro, H. E. Brown, R. A. Ward, D. A. V. Blanco, K. D. Timmer, M. K. Mansour, M. Wüthrich, T. Fontaine, J.-P. Latgé, J. M. Vyas

This study identifies Dectin-2 as a receptor for Aspergillus fumigatus galactomannan, showing it mediates pro-inflammatory signaling and immune responses.

bioRxiv · Apr 12, 2022Immunology

Internalization of the host alkaline pH signal in a fungal pathogen

H. E. Brown, J. A. Alspaugh, K. M. Pianalto, K. D. Mueller, C. M. Fernandes, M. Del Poeta

This study identifies how the Rra1 protein in Cryptococcus neoformans internalizes and recycles in response to alkaline pH, enabling the fungus to adapt to the human host environment.

bioRxiv · Oct 19, 2020 · PreprintCell Biology

Sterol-response pathways mediate alkaline survival in diverse fungi

H. E. Brown, C. L. Telzrow, J. W. Saelens, L. Fernandes, J. A. Alspaugh

This study identifies the sterol homeostasis pathway as essential for fungal survival at alkaline pH, independent of the Rim pathway, and shows increased susceptibility to antifungals under alkaline conditions.

bioRxiv · Mar 26, 2020Microbiology