Author

C. Choi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 2 Biochemistry· 1 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 5 Research Focus:cell signaling & trafficking· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:imaging· 2 Assay:proteomics· 2

Frequent Co-Authors

C. de Aguiar Ferreira· 2 shared D. T. Hung· 2 shared J. J. Grudzinski· 2 shared J. Lee· 2 shared O. Kwon· 2 shared R. Hernandez· 2 shared A. Anneken· 1 shared A. Bellofiore· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCancer Biology

C. de Aguiar Ferreira

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11 papers

Recent·Most cited

Effects of clinically relevant radionuclides on the activation of a type I interferon response by radiopharmaceuticals in syngeneic murine tumor models

C. P. Kerr, J. Sheehan-Klenk, J. J. Grudzinski, D. P. Adam, T. P. T. Nguyen, C. de Aguiar Ferreira, A. M. Bates, W. J. Jin, O. Kwon, A. P. Olson, W. Lin, M. Hyun, J. C. Jagodinsky, M. Powers, R. N. Sriramaneni, , Z. S. Morris

This study examines how different radionuclides affect the type I interferon response in tumor models and shows that 225Ac enhances immunotherapy response via STING-dependent mechanisms.

bioRxiv · Jul 10, 2024 · PreprintCancer Biology

Structural basis for CCR6 modulation by allosteric antagonists

D. J. Wasilko, B. S. Gerstenberger, K. A. Farley, W. Li, J. Alley, M. E. Schnute, R. J. Unwalla, J. Victorino, K. K. Crouse, R. Ding, P. V. Sahasrabudhe, F. Vincent, R. K. Frisbie, A. Dermenci, A. Flick, , H. Wu

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

bioRxiv · Apr 5, 2024Biochemistry

A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors

M. Parada-Kusz, A. E. Clatworthy, E. R. Goering, S. M. Blackwood, E. J. Salm, C. Choi, S. Combs, J. S. Lee, C. Rodriguez-Osorio, S. Tomita, D. T. Hung

The paper identifies 3-hydroxy-kynurenine as a tryptophan metabolite that enhances host survival during bacterial infection by modulating kainate receptors in macrophages.

bioRxiv · Aug 16, 2023Immunology

Profound immunomodulatory effects of 225Ac-NM600 drive enhanced anti-tumor responsein prostate cancer

C. de Aguiar Ferreira, H. K. Potluri, C. Massey, J. J. Grudzinski, A. Carston, N. Clemons, A. S. Thickens, Z. Rosenkrans, C. Choi, A. Pinchuk, O. Kwon, J. J. Jeffery, B. Bednarz, Z. Morris, J. Weichert, , R. Hernandez

This study shows that 225Ac-NM600, an alpha-emitting radiopharmaceutical, enhances anti-tumor responses in prostate cancer by modulating the immune microenvironment.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

S. An, A. Anneken, Z. Xi, C. Choi, J. Schlessinger, D. Toomre

This study shows that exocyst-mediated exocytosis regulates PI(3,4,5)P3 levels and AKT activation in response to EGF signaling in epithelial cells.

bioRxiv · Mar 21, 2022Cell Biology

Antibiotic action revealed by real-time imaging of the mycobacterial membrane

M. G. Wuo, C. L. Dulberger, R. A. Brown, A. Sturm, E. Ultee, Z. Bloom-Ackermann, C. Choi, E. C. Garner, A. Briegel, D. T. Hung, E. J. Rubin, L. L. Kiessling

This study uses real-time imaging to observe how antibiotics affect mycobacterial cell envelope remodeling, revealing unique cellular responses and extracellular vesicle production.

bioRxiv · Jan 7, 2022 · PreprintMicrobiology

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

B. D. Reed, M. J. Meyer, V. Abramzon, O. Ad, P. Adcock, F. R. Ahmad, G. Alppay, J. A. Ball, J. Beach, D. Belhachemi, A. Bellofiore, M. Bellow, J. Felipe Beltran, A. Betts, M. Wadud Bhuiya, , X. Ma

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

bioRxiv · Jan 4, 2022Biophysics

Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the Epidermal Growth Factor Receptor

M. Resnik-Docampo, K. M. Cunningham, S. M. Ruvalcaba, C. Choi, V. Sauer, D. L. Jones

This study shows Neuroglian enhances EGFR signaling in Drosophila intestinal stem cells, promoting proliferation and affecting age-related changes.

bioRxiv · Nov 17, 2020Cell Biology

Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog

S. Roberts, E. Khera, C. Choi, T. Navaratna, J. Grimm, G. M. Thurber, T. Reiner

This paper develops and validates a near-infrared optoacoustic contrast agent for imaging GLP-1R-expressing cells in vivo.

bioRxiv · Apr 29, 2020Bioengineering

High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

O.-H. Kim, C. J. Booth, H. S. Choi, J. Lee, J. Kang, J. Hur, H. J. Choi, H. Kim, J.-H. Auh, J.-Y. Cha, Y. J. Lee, C. S. Lee, C. Choi, J.-y. Yang, S.-S. Im, , B.-C. Oh

This study shows that a high-phytate/low-calcium diet causes crystal nephropathies, renal phosphate wasting, and bone loss in rats through tubular dysfunction and altered mineral absorption.

bioRxiv · Oct 29, 2019Physiology

DUSP28 is a novel biomarker responsible for aggravating malignancy via the autocrine signaling pathways in metastatic pancreatic cancer

J. H. Kim, J. Lee, J. Lee, C. Choi

This study identifies DUSP28 as a biomarker that promotes metastatic pancreatic cancer progression through autocrine signaling pathways and pro-angiogenic effects.

bioRxiv · May 3, 2018Cancer Biology