Author

H. J. Sharpe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

I. M. Hay· 2 shared J. E. Deane· 2 shared A. Li· 1 shared A. Prasnicka· 1 shared A. S. A. Mohammed· 1 shared C. M. Jeffries· 1 shared D. C. Hay· 1 shared D. Ezerina· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

I. M. Hay

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

E. H. Gilglioni, A. Li, W. Saint-Pierre Wijckmans, T.-K. Shen, I. Perez-Chavez, G. Hovhannisyan, M. Lisjak, J. Negueruela, V. Vandenbempt, J. Bauza-Martinez, J. M. Herranz, D. Ezerina, S. Demine, Z. Feng, T. Vignane, , E. N. Gurzov

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

bioRxiv · Dec 1, 2023 · PreprintCancer Biology

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

I. M. Hay, M. Shamin, E. R. Caroe, A. S. A. Mohammed, D. I. Svergun, C. M. Jeffries, S. C. Graham, H. J. Sharpe, J. E. Deane

This study compares the structural features of PTPRK and PTPRM extracellular domains to identify determinants of homophilic adhesion, finding that shape complementarity and limited sequence differences drive specificity.

bioRxiv · Jun 23, 2022Biochemistry

The receptor PTPRU is a redox sensitive pseudophosphatase

I. M. Hay, G. W. Fearnley, P. Rios, M. Koehn, H. J. Sharpe, J. E. Deane

This paper shows that PTPRU is a pseudophosphatase with no catalytic activity, functioning instead by competing with active phosphatases for substrate binding.

bioRxiv · Oct 16, 2019Biochemistry