Author

I. M. Hay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

H. J. Sharpe· 2 shared J. E. Deane· 2 shared A. S. A. Mohammed· 1 shared A. Y. Warren· 1 shared C. M. Jeffries· 1 shared C. N. Pacyna· 1 shared D. I. Svergun· 1 shared E. R. Caroe· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

H. J. Sharpe

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Author profile →

3 papers

Recent·Most cited

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

C. N. Pacyna, M. Anandapadamanaban, K. W. Loudon, I. M. Hay, O. Perisic, R. Li, M. Byrne, L. Allen, K. Roberts, Y. Hooks, A. Y. Warren, G. D. Stewart, M. R. Clatworthy, S. Teichmann, S. Behjati, , T. J. Mitchell

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

bioRxiv · Dec 12, 2023Cancer Biology

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

I. M. Hay, M. Shamin, E. R. Caroe, A. S. A. Mohammed, D. I. Svergun, C. M. Jeffries, S. C. Graham, H. J. Sharpe, J. E. Deane

This study compares the structural features of PTPRK and PTPRM extracellular domains to identify determinants of homophilic adhesion, finding that shape complementarity and limited sequence differences drive specificity.

bioRxiv · Jun 23, 2022Biochemistry

The receptor PTPRU is a redox sensitive pseudophosphatase

I. M. Hay, G. W. Fearnley, P. Rios, M. Koehn, H. J. Sharpe, J. E. Deane

This paper shows that PTPRU is a pseudophosphatase with no catalytic activity, functioning instead by competing with active phosphatases for substrate binding.

bioRxiv · Oct 16, 2019Biochemistry