Author

H. Jasper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Jain· 2 shared C. Dillard· 2 shared T. E. Rusten· 2 shared A. Ashworth· 1 shared A. Brech· 1 shared A. Dey· 1 shared A. H. Jahren· 1 shared C. L. Noland· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

A. Jain

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Oncogenic Ras-driven Dorsal/NF-κB signaling contributes to tumorigenesis in a Drosophila carcinoma model

C. Dillard, J. Teles-Reis, A. Jain, R. Le Borgne, H. Jasper, T. E. Rusten

This study shows that oncogenic RasV12 activates Dorsal/NF-κB signaling, promoting tumor growth and malignancy in Drosophila melanogaster tumors.

bioRxiv · May 8, 2024 · PreprintCancer Biology

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

T. H. Pham, K. B. Pahuja, T. J. Hagenbeek, J. Zbieg, C. L. Noland, V. C. Pham, X. Yao, C. M. Rose, K. C. Browder, H.-J. Lee, M. Yu, M. Liang-Chu, S. E. Martin, E. Verschueren, J. Li, , A. Dey

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

bioRxiv · Oct 3, 2023 · PreprintCancer Biology

Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury.

H. Jasper, D. J.-K. Hu, J. Yun, J. Elstrott

This study shows that enteroendocrine cells release Otk, activating non-canonical Wnt signaling in intestinal stem cells to promote their directed migration to injury sites in Drosophila.

bioRxiv · Sep 15, 2021Cell Biology

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth

T. E. Rusten, R. Khezri, P. Holland, T. A. Schoborg, I. Abramovich, S. Takats, C. Dillard, A. Jain, F. OFarrell, S. Schultz, W. Hagopian, E. M. Quintana, R. Ng, N. S. Katheder, M. M. Rahman, , E. Gottlieb

The paper shows that host autophagy drives organ wasting and nutrient mobilization to support tumor growth in Drosophila.

bioRxiv · Dec 4, 2020Cell Biology

JNK-mediated spindle reorientation in stem cells promotes dysplasia in the aging intestine

D. Hu, H. Jasper

This study shows that JNK-mediated spindle reorientation in Drosophila intestinal stem cells leads to increased symmetric divisions and contributes to aging-related dysplasia.

bioRxiv · Jul 11, 2018 · PreprintCell Biology