H. Jiang

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry

This paper develops a method to simultaneously quantify and trace dNTP metabolites using isotope dilution and high-resolution mass spectrometry, showing improved accuracy and metabolic pathway insights.

The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

Identification and Quantification of Paclitaxel and its Metabolites in Human Meconium from Newborns with Gestational Chemotherapeutic Exposure

The paper detects paclitaxel and its metabolites in meconium from newborns exposed to chemotherapy in utero, showing variability in fetal exposure levels.

Artefactual formation of pyruvate from in-source conversion of lactate

The paper identifies an artefactual pyruvate formation from lactate during LC-MS analysis, highlighting the need for improved resolution or quantification in metabolomics studies.

In situ administration of cytokine combinations induces tumor regression

This study shows that in situ administration of cytokine combinations can induce complete tumor regression in mice, including large tumors, through strong synergistic effects and systemic antitumor immunity.

Time dependent genetic analysis links field and controlled environment phenotypes in the model C4 grass Setaria

This study links field and controlled environment plant height phenotypes in Setaria using genetic analysis, showing height is heritable, polygenic, and influenced by environmental factors and developmental timing.