H. Jiang

Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

The apple palmitoyltransferase MdPAT16 regulates sugar content via an MdCBL1-MdCIPK13-MdSUT2.2 pathway

This study identifies MdPAT16 as a palmitoyltransferase that enhances salt resistance and regulates apple sugar content through the MdCBL1-MdCIPK13-MdSUT2.2 pathway.

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

This paper develops FeADCs, ferrous iron-activatable drug conjugates, to target KRAS-driven cancers with improved tumor selectivity and systemic tolerability.

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

This study shows that BMP9 protects pulmonary endothelium during inflammation-induced lung injury and that exogenous BMP9 can prevent lung injury in mice.

Affinity proteomic dissection of the human nuclear cap-binding-complex interactome

This study maps the human nuclear cap-binding complex interactome using affinity proteomics to clarify the composition and interactions of NCBP1, NCBP2, and NCBP3-related macromolecular assemblies.

Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

PacBio SMRT-based full-length transcriptome data of Ascosphaera apis mycelium and spore

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

Facing small and biased data dilemma in drug discovery with federated learning

This paper applies federated learning to drug discovery, showing it improves prediction accuracy over centralized training with biased and small datasets.

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

Intracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis

This study demonstrates that intracorneal delivery of HSV-1-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis in both animal models and human-derived corneas.

A Heat Stress Responsive NAC Transcription Factor Heterodimer Plays Key Roles in Rice Grain Filling

This study identifies two heat stress-responsive NAC transcription factors in rice that regulate grain filling and sugar transport through a heterodimer complex.

A novel antiviral lncRNA EDAL shields a T309 O-GlcNAcylation site to promote EZH2 degradation

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

Defining relative mutational difficulty to understand cancer formation and prevention

The paper introduces a method to predict the functionality of low-frequency missense mutations by integrating mutation counts with relative mutational difficulty, revealing functional p53 mutations and potential cancer prevention strategies.

Diverse flanking sequence types of blaNDM in IncX3 and IncB/O/K/Z plasmids in Escherichia coli isolated from poultry

The paper identifies diverse flanking sequences of blaNDM in specific plasmids from E. coli isolated from poultry, highlighting the role of IS26 in plasmid evolution.

A new strategy for selection of crop cultivated varieties based on yield factors driving and meteorological prediction

This paper proposes a strategy to select crop varieties based on yield factors and meteorological predictions, showing 70% and 50% success rates in two pilot regions for soybean variety selection.

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

The paper corrects for artifactual post-harvest metabolism in subcellular isotope tracing to reveal compartment-specific metabolic kinetics.

LINE-1 ORF2P EXPRESSION IS NEARLY IMPERCEPTIBLE IN HUMAN CANCERS

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL and NCK1

This study identifies TNK2, WASL, and NCK1 as host factors critical for multiple picornavirus infections, showing they function in a common pathway during viral entry.

In situ Fucosylation for Modulating Wnt Signaling in Live Cells

This study shows that fucosylation of N-glycans modulates Wnt signaling by affecting LRP6 endocytosis, revealing a new glycosylation-dependent regulatory mechanism.

Suppression of p16 increases nucleotide synthesis via mTORC1

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

The C. elegans RIG-I homolog drh-1 mediates the Intracellular Pathogen Response upon viral infection

This paper shows that drh-1 in C. elegans mediates the Intracellular Pathogen Response (IPR) to viral infection, acting as a pattern-recognition receptor independent of its role in RNAi.

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

Degradation of miR-466d-3p by JEV NS3 facilitates viral replication and IL-1β expression

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

Identification of lumbrokinase by fibrin-plate method, fibrin-zymography and liquid chromatography mass spectrometry

This study identifies lumbrokinase components using fibrin plate method, fibrin-zymography, and mass spectrometry, revealing fibrinolytic and kinase activities similar to trypsin and plasminogen activators.

FOP plays a negative role in ciliogenesis and promotes cell cycle re-entry by facilitating primary cilia disassembly

This study shows FOP negatively regulates ciliogenesis by promoting cilia disassembly and facilitates cell cycle re-entry.

Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth

The paper develops DPY30-targeting peptides that inhibit blood cancer cell growth by disrupting ASH2L binding and H3K4 methylation.

Effects of Lactobacillus plantarum 15-1 and fructooligosaccharide on the response of broilers to pathogenic Escherichia coli O78 challenge

This study evaluates the effects of Lactobacillus plantarum 15-1 and fructooligosaccharide on broiler chickens challenged with E. coli O78, showing improved intestinal morphology, reduced intestinal injury, and enhanced immune responses.

The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death

This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.