Author

J. V. Heymach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

H. Kadara· 3 shared J. Zhang· 3 shared A. E. Spira· 2 shared A. Sinjab· 2 shared B. Sepesi· 2 shared C. S. Stevenson· 2 shared D. L. Gibbons· 2 shared E. Dai· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

H. Kadara

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5 papers

Recent·Most cited

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

G. Han, A. Sinjab, Z. Rahal, A. M. Lynch, W. Treekitkarnmongkol, Y. Liu, A. G. Serrano, J. Feng, K. Liang, K. Khan, W. Lu, S. Hernandez, Y. Liu, X. Cao, E. Dai, , H. Kadara

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

bioRxiv · May 13, 2022Cancer Biology

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

A. Sinjab, G. Han, W. Treekitkarnmongkol, K. Kobayashi, P. Brennan, M. Dang, D. Hao, R. Wang, E. Dai, H. Dejima, J. Zhang, E. Bogatenkova, B. Sanchez-Espiridion, K. Chang, D. R. Little, , H. Kadara

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology

C. A. Stewart, C. M. Gay, K. Ramkumar, K. R. Cargill, R. J. Cardnell, M. B. Nilsson, S. Heeke, E. M. Park, S. T. Kundu, L. Diao, Q. Wang, L. Shen, Y. Xi, B. Zhang, C. M. Della Corte, , L. A. Byers

The paper investigates how SARS-CoV-2 infection induces epithelial-mesenchymal transition (EMT) in lung cancer models, leading to changes in gene expression and potential therapeutic targets.

bioRxiv · May 28, 2020 · PreprintCancer Biology

METABOLIC DIVERSITY IN HUMAN NON-SMALL CELL LUNG CANCER CELLS

P.-H. CHEN, L. Cai, C. Yang, J. Kim, B. Faubert, L. Boroughs, B. Ko, J. Sudderth, E. A. McMillan, L. Girard, M. Peyton, K. Huffman, M. D. Shields, D. Shames, H. S. Kim, , R. J. DeBerardinis

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.

bioRxiv · Mar 11, 2019Cancer Biology

Simplified Molecular Classification of Lung Adenocarcinomas Based on EGFR, KRAS, and TP53 Mutations

R. Ruiz-Cordero, J. Ma, A. Khanna, G. Lyons, W. Rinsurongkawong, R. Bassett, M. Guo, M. J. Routbort, J. Zhang, F. Sloulidis, J. V. Heymach, E. B. Roarty, Z. Tang, L. J. Medeiros, K. P. Patel, , S. Roy-Chowdhuri

This paper classifies lung adenocarcinomas into six subtypes based on EGFR, KRAS, and TP53 mutations, finding associations with prognosis and validating the classification against clinical outcomes.

bioRxiv · Jan 21, 2019Cancer Biology