Author

H. L. Horsnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 4

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. E. Acton· 3 shared A. C. Benjamin· 2 shared S. Makris· 2 shared V. G. Martinez· 2 shared A. Benjamin· 1 shared A. Denton· 1 shared C. J. Tape· 1 shared C. M. de Winde· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

S. E. Acton

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4 papers

Recent·Most cited

The transcription factor SpiB regulates Fibroblastic Reticular Cell network and CD8+ T cell responses in lymph nodes

H. L. Horsnell, W. H. Cao, G. T. Belz, S. N. Mueller, Y. O. Alexandre

This study shows that SpiB regulates FRC network structure and CD8+ T cell responses in lymph nodes by affecting FRC function and immune coordination.

bioRxiv · Oct 12, 2023Immunology

Lymph node fibroblast phenotypes and immune crosstalk regulated by Podoplanin activity

S. Makris, Y. Hari-Gupta, J. A. Cantoral-Rebordinos, V. G. Martinez, H. L. Horsnell, A. Benjamin, I. Cinti, D. Shewring, N. Nguyen, M. Jovancheva, C. M. de Winde, A. Denton, S. E. Acton

This study shows that Podoplanin deletion in fibroblastic reticular cells increases inflammatory signaling and disrupts stromal-immune crosstalk in lymph nodes.

bioRxiv · Dec 1, 2022Immunology

Tissue homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics

H. L. Horsnell, R. J. Tetley, H. de Belly, S. Makris, A. C. Benjamin, E. Paluch, Y. Mao, S. E. Acton

This study identifies how fibroblast network mechanics regulate tissue tension and adaptation to immune challenge in lymph nodes.

bioRxiv · May 27, 2021Immunology

Conduit integrity is compromised during acute lymph node expansion

V. G. Martinez, V. Pankova, L. Krasny, T. Singh, I. J. White, A. C. Benjamin, S. Dertschnig, H. L. Horsnell, J. Kriston-Vizi, J. J. Burden, P. H. Huang, C. J. Tape, S. E. Acton

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.

bioRxiv · Mar 21, 2019Immunology