Author

S. E. Acton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 3 Biochemistry· 1 Cancer Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:development & morphogenesis· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3

Frequent Co-Authors

V. G. Martinez· 5 shared A. C. Benjamin· 4 shared C. M. de Winde· 4 shared H. L. Horsnell· 3 shared S. Makris· 3 shared C. J. Tape· 2 shared L. Krasny· 2 shared P. H. Huang· 2 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

V. G. Martinez

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Lymph node fibroblast phenotypes and immune crosstalk regulated by Podoplanin activity

S. Makris, Y. Hari-Gupta, J. A. Cantoral-Rebordinos, V. G. Martinez, H. L. Horsnell, A. Benjamin, I. Cinti, D. Shewring, N. Nguyen, M. Jovancheva, C. M. de Winde, A. Denton, S. E. Acton

This study shows that Podoplanin deletion in fibroblastic reticular cells increases inflammatory signaling and disrupts stromal-immune crosstalk in lymph nodes.

bioRxiv · Dec 1, 2022Immunology

Tissue homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics

H. L. Horsnell, R. J. Tetley, H. de Belly, S. Makris, A. C. Benjamin, E. Paluch, Y. Mao, S. E. Acton

This study identifies how fibroblast network mechanics regulate tissue tension and adaptation to immune challenge in lymph nodes.

bioRxiv · May 27, 2021Immunology

Fibroblastic Reticular Cell Response to Dendritic Cells Requires Coordinated Activity of Podoplanin, CD44 and CD9

C. M. de Winde, S. Makris, L. Millward, J. Cantoral, A. C. Benjamin, V. G. Martinez, S. E. Acton

This study identifies that podoplanin, CD44, and CD9 are coregulated on fibroblastic reticular cells (FRCs) and work together to regulate FRC response to CLEC-2+ dendritic cells during lymph node expansion.

bioRxiv · Nov 20, 2020Cell Biology

Podoplanin drives dedifferentiation and amoeboid invasion of melanoma

C. M. de Winde, S. L. George, A. Arp, A. C. Benjamin, E. Crosas-Molist, Y. Hari-Gupta, A. Carver, V. Imperatore, V. G. Martinez, V. Sanz-Moreno, S. E. Acton

This study shows podoplanin promotes amoeboid invasion and dedifferentiation in melanoma, suggesting it as a biomarker and therapeutic target.

bioRxiv · Jul 23, 2020Cancer Biology

A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

L. Krasny, P. Bland, J. Burns, N. C. Lima, P. T. Harrison, L. Pacini, M. L. Elms, J. Ning, V. G. Martinez, Y.-R. Yu, S. E. Acton, P.-C. Ho, F. Calvo, A. Swain, B. A. Howard, , P. H. Huang

The paper develops a mouse SWATH-MS spectral library and a deconvolution method to analyze proteomic changes in human tumor xenografts, revealing host-tumor interactions.

bioRxiv · Feb 3, 2020Biochemistry

Single-Cell Signalling Analysis of Heterocellular Organoids

X. Qin, J. Sufi, P. Vlckova, P. Kyriakidou, S. E. Acton, V. S. W. Li, M. Nitz, C. J. Tape

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.

bioRxiv · Nov 11, 2019Cell Biology

Conduit integrity is compromised during acute lymph node expansion

V. G. Martinez, V. Pankova, L. Krasny, T. Singh, I. J. White, A. C. Benjamin, S. Dertschnig, H. L. Horsnell, J. Kriston-Vizi, J. J. Burden, P. H. Huang, C. J. Tape, S. E. Acton

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.

bioRxiv · Mar 21, 2019Immunology

The life of P.I. - Transitions to Independence in Academia

S. E. Acton, A. Bell, C. P. Toseland, A. Twelvetrees

This report analyzes data from 365 UK-based principle investigators to identify challenges in transitioning to academic independence and suggests policy and support improvements.

bioRxiv · Mar 12, 2019Scientific Communication & Education

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37

C. M. de Winde, A. L. Matthews, S. van Deventer, A. van der Schaaf, N. D. Tomlinson, E. Jansen, J. A. Eble, B. Nieswandt, H. M. McGettrick, C. G. Figdor, S. E. Acton, M. G. Tomlinson, A. B. van Spriel

This study shows that CD37 stabilizes CLEC-2 membrane expression and regulates DC migration to lymph nodes via interactions with podoplanin.

bioRxiv · Dec 22, 2017Cell Biology