Author

C. M. de Winde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. E. Acton· 4 shared V. G. Martinez· 3 shared A. C. Benjamin· 2 shared S. Makris· 2 shared Y. Hari-Gupta· 2 shared A. Arp· 1 shared A. B. van Spriel· 1 shared A. Benjamin· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

S. E. Acton

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Author profile →

5 papers

Recent·Most cited

Unbiased method for spectral analysis of cells with great diversity of autofluorescence spectra

J. E. G. Roet, A. M. Mikula, M. de Kok, C. H. Chadick, J. J. Garcia Vallejo, H. P. Roest, L. J. W. van der Laan, C. M. de Winde, R. E. Mebius

This paper introduces an unbiased method to identify and account for heterogeneous autofluorescence spectra in flow cytometry data, improving unmixing accuracy across diverse biological samples.

bioRxiv · Jul 28, 2023Cell Biology

Lymph node fibroblast phenotypes and immune crosstalk regulated by Podoplanin activity

S. Makris, Y. Hari-Gupta, J. A. Cantoral-Rebordinos, V. G. Martinez, H. L. Horsnell, A. Benjamin, I. Cinti, D. Shewring, N. Nguyen, M. Jovancheva, C. M. de Winde, A. Denton, S. E. Acton

This study shows that Podoplanin deletion in fibroblastic reticular cells increases inflammatory signaling and disrupts stromal-immune crosstalk in lymph nodes.

bioRxiv · Dec 1, 2022Immunology

Fibroblastic Reticular Cell Response to Dendritic Cells Requires Coordinated Activity of Podoplanin, CD44 and CD9

C. M. de Winde, S. Makris, L. Millward, J. Cantoral, A. C. Benjamin, V. G. Martinez, S. E. Acton

This study identifies that podoplanin, CD44, and CD9 are coregulated on fibroblastic reticular cells (FRCs) and work together to regulate FRC response to CLEC-2+ dendritic cells during lymph node expansion.

bioRxiv · Nov 20, 2020Cell Biology

Podoplanin drives dedifferentiation and amoeboid invasion of melanoma

C. M. de Winde, S. L. George, A. Arp, A. C. Benjamin, E. Crosas-Molist, Y. Hari-Gupta, A. Carver, V. Imperatore, V. G. Martinez, V. Sanz-Moreno, S. E. Acton

This study shows podoplanin promotes amoeboid invasion and dedifferentiation in melanoma, suggesting it as a biomarker and therapeutic target.

bioRxiv · Jul 23, 2020Cancer Biology

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37

C. M. de Winde, A. L. Matthews, S. van Deventer, A. van der Schaaf, N. D. Tomlinson, E. Jansen, J. A. Eble, B. Nieswandt, H. M. McGettrick, C. G. Figdor, S. E. Acton, M. G. Tomlinson, A. B. van Spriel

This study shows that CD37 stabilizes CLEC-2 membrane expression and regulates DC migration to lymph nodes via interactions with podoplanin.

bioRxiv · Dec 22, 2017Cell Biology