Author

V. G. Martinez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

S. E. Acton· 5 shared A. C. Benjamin· 3 shared C. M. de Winde· 3 shared H. L. Horsnell· 2 shared L. Krasny· 2 shared P. H. Huang· 2 shared S. Makris· 2 shared Y. Hari-Gupta· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

S. E. Acton

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Comprehensive Landscape of Non-muscle Invasive Bladder Cancer Tumour Microenvironment and Prognostic value of Cancer-Associated Myofibroblasts

C. M. Canizo, F. Guerrero-Ramos, M. Perez-Escavy, I. Lodewijk, C. Suarez-Cabrera, L. Morales, S. P. Nunes, E. Munera-Maravilla, C. Rubio, R. Sanchez, M. Rodriguez-Izquierdo, J. Martinez de Villarreal, F. X. Real, D. Castellano, C. Martin-Arriscado, , V. G. Martinez

The paper analyzes the tumor microenvironment of NMIBC, finding that cancer-associated myofibroblasts are prognostic markers for progression and recurrence.

bioRxiv · Oct 26, 2023 · PreprintCancer Biology

Lymph node fibroblast phenotypes and immune crosstalk regulated by Podoplanin activity

S. Makris, Y. Hari-Gupta, J. A. Cantoral-Rebordinos, V. G. Martinez, H. L. Horsnell, A. Benjamin, I. Cinti, D. Shewring, N. Nguyen, M. Jovancheva, C. M. de Winde, A. Denton, S. E. Acton

This study shows that Podoplanin deletion in fibroblastic reticular cells increases inflammatory signaling and disrupts stromal-immune crosstalk in lymph nodes.

bioRxiv · Dec 1, 2022Immunology

Fibroblastic Reticular Cell Response to Dendritic Cells Requires Coordinated Activity of Podoplanin, CD44 and CD9

C. M. de Winde, S. Makris, L. Millward, J. Cantoral, A. C. Benjamin, V. G. Martinez, S. E. Acton

This study identifies that podoplanin, CD44, and CD9 are coregulated on fibroblastic reticular cells (FRCs) and work together to regulate FRC response to CLEC-2+ dendritic cells during lymph node expansion.

bioRxiv · Nov 20, 2020Cell Biology

Podoplanin drives dedifferentiation and amoeboid invasion of melanoma

C. M. de Winde, S. L. George, A. Arp, A. C. Benjamin, E. Crosas-Molist, Y. Hari-Gupta, A. Carver, V. Imperatore, V. G. Martinez, V. Sanz-Moreno, S. E. Acton

This study shows podoplanin promotes amoeboid invasion and dedifferentiation in melanoma, suggesting it as a biomarker and therapeutic target.

bioRxiv · Jul 23, 2020Cancer Biology

A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

L. Krasny, P. Bland, J. Burns, N. C. Lima, P. T. Harrison, L. Pacini, M. L. Elms, J. Ning, V. G. Martinez, Y.-R. Yu, S. E. Acton, P.-C. Ho, F. Calvo, A. Swain, B. A. Howard, , P. H. Huang

The paper develops a mouse SWATH-MS spectral library and a deconvolution method to analyze proteomic changes in human tumor xenografts, revealing host-tumor interactions.

bioRxiv · Feb 3, 2020Biochemistry

Conduit integrity is compromised during acute lymph node expansion

V. G. Martinez, V. Pankova, L. Krasny, T. Singh, I. J. White, A. C. Benjamin, S. Dertschnig, H. L. Horsnell, J. Kriston-Vizi, J. J. Burden, P. H. Huang, C. J. Tape, S. E. Acton

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.

bioRxiv · Mar 21, 2019Immunology

Overexpression Of Hypoxia-Inducible Factor 1 Alpha Improves Immunomodulation By Dental Mesenchymal Stem Cells

V. G. Martinez, I. Ontoria-Oviedo, C. P. Ricardo, S. E. Harding, R. Sacedon, A. Varas, A. Zapata, P. Sepulveda, A. Vicente

This study shows that overexpressing HIF-1 alpha in dental mesenchymal stem cells enhances their immunomodulatory abilities and resistance to NK cell lysis, improving their therapeutic potential.

bioRxiv · May 24, 2017Immunology