Author

H. Lee-Six

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. J. Campbell· 3 shared I. Martincorena· 2 shared K. Saeb-Parsy· 2 shared L. Moore· 2 shared M. A. Sanders· 2 shared M. R. Stratton· 2 shared P. Ellis· 2 shared A. Akarca· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

P. J. Campbell

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Author profile →

3 papers

Recent·Most cited

Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer

A. Pennycuick, V. H. Teixeira, K. AbdulJabbar, S. E. A. Raza, T. Lund, A. Akarca, R. Rosenthal, C. P. Pipinikas, H. Lee-Six, D. P. Chandrasekharan, R. E. Hynds, K. H. C. Gowers, J. Y. Henry, C. Denais, M. Falzon, , S. M. Janes

The paper investigates immune surveillance in pre-invasive squamous cell lung cancer, finding that regressive lesions have more immune infiltration and distinct molecular profiles compared to progressive lesions.

bioRxiv · Nov 10, 2019Cancer Biology

The mutational landscape of normal human endometrial epithelium

L. Moore, D. Leongamornlert, T. H. Coorens, M. A. Sanders, P. Ellis, K. Dawson, F. Maura, J. Nangalia, P. S. Tarpey, S. F. Brunner, H. Lee-Six, R. Rahbari, S. Moody, Y. Hooks, K. Mahbubani, , M. R. Stratton

This study characterizes the mutational landscape of normal human endometrial epithelium, revealing age-related mutation burdens and driver mutations in cancer genes.

bioRxiv · Dec 24, 2018Cancer Biology

The landscape of somatic mutation in normal colorectal epithelial cells

H. Lee-Six, P. Ellis, R. J. Osborne, M. A. Sanders, L. Moore, N. Georgakopoulos, F. Torrente, A. Noorani, M. Goddard, P. Robinson, T. H. H. Coorens, L. O'Neill, C. Alder, J. Wang, R. C. Fitzgerald, , M. R. Stratton

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.

bioRxiv · Sep 13, 2018Cancer Biology