R. Jenkins

Deciphering the diversity and sequence of extracellular matrix and cellular spatial patterns in lung adenocarcinoma using topological data analysis

This study uses topological data analysis to quantify ECM architecture and spatial patterns in lung adenocarcinoma, revealing progressive changes linked to immune exclusion and metabolic shifts.

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

Are narrow-ranging species doomed to extinction? Projected dramatic decline in future climate suitability of two highly threatened species

This study predicts a dramatic decline in climate suitability for two narrow-ranging species by 2070, suggesting potential extinction and highlighting the need for conservation actions.

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

The paper shows that IDH mutations other than p.R132H in 1p/19q non-codeleted astrocytomas are linked to higher DNA methylation and better patient survival.

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote beta cell regeneration

Full Emergence timing and voltinism of phantom midges, Chaoborus spp., in the UK

This study investigates the emergence timing and voltinism of Chaoborus spp. midges in UK microcosms, finding mass spring emergence of C. obscuripes and up to four generations of C. crystallinus.