J. Niu

Multi-decadal warming alters predator's effect on prey community composition

The paper shows that multi-decadal warming leads to predator adaptations that alter prey community composition through trophic interactions.

Lack of dominant-negative activity for tumor-associated ZNRF3 missense mutations at endogenous expression levels

This study shows that tumor-associated ZNRF3 missense mutations do not exhibit dominant-negative activity and instead act as loss-of-function mutations at endogenous levels.

Perinuclear force regulates SUN2 dynamics and distribution on the nuclear envelope for proper nuclear mechanotransduction

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

Mutation of IDR1 enhances drought tolerance by reducing ROS production and activating ROS scavenging in rice

Click-PD: A Quantitative Method for Base-Modified Aptamer Discovery

This paper introduces click-PD, a method for discovering base-modified aptamers with high affinity and specificity using click chemistry and FACS screening.

Imaging chromatin interactions at sub-kilobase resolution Via Tn5-FISH

This paper introduces Tn5-FISH, a method to visualize chromatin interactions at sub-kilobase resolution and validate results from 3C-derivative methods.

SmbHLH37 functions antagonistically with SmMYC2 in regulating jasmonate-mediated biosynthesis of phenolic acids in Salvia miltiorrhiza

This study identifies SmbHLH37 as an antagonist of SmMYC2 in regulating jasmonate-mediated phenolic acid biosynthesis in Salvia miltiorrhiza.