J. Oberholzer

Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum

PPCN, a thermoresponsive antioxidant polymer, supports islet viability and function in nonhuman primates when used for omentum transplantation.

SHRIMP: Genetically Encoded mScarlet-derived Red Fluorescent Hydrogen Peroxide Sensor with High Brightness and Minimal Photoactivation

This paper develops SHRIMP, a genetically encoded red fluorescent hydrogen peroxide sensor with high brightness and minimal photoactivation, validated in mammalian cells and primary islet tissue.

Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Pancreatic Islets

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.