M. Shetty

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

The Microtubule Severing Protein UNC-45A Counteracts the Microtubule Straightening Effects of Taxol

This paper shows UNC-45A increases microtubule curvature and counteracts Taxol's straightening effects, suggesting a role in drug resistance.

Fecal Microbiota Restoration Modulates the Microbiome in Inflammation-Driven Colorectal Cancer

The paper examines microbiome changes in inflammation-driven colorectal cancer using a mouse model, finding increased Akkermansia in microbiome-restored mice and elevated lipocalin-2 in unrestored animals.

GLS1 is a Protective Factor Rather than a Molecular Target in ARID1A-Mutated Ovarian Clear Cell Carcinoma

The paper investigates GLS1 expression in ARID1A-mutated ovarian clear cell carcinoma and finds it is not correlated with ARID1A loss and is associated with better clinical outcomes.

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

This study shows that loss of ARID1A increases mitochondrial metabolism in OCCC and that inhibiting mitochondrial complex I improves survival in preclinical models.

UNC-45A Weakens and Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

This study shows UNC-45A weakens and breaks microtubule lattices independently of its effect on non-muscle myosin II, with implications for disease treatment.

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.

UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

This paper shows UNC-45A is preferentially expressed in epithelial cells and co-localizes with microtubules in interphase cells, independent of actin or myosin.