H. Peng

This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.

The paper reports cryo-EM structures of the SARS-CoV-2 spike protein with the D614G substitution, showing how the mutation affects trimer stability and infectivity.

The paper designs de novo ACE2 protein decoys to neutralize SARS-CoV-2 by blocking viral entry, showing high affinity and potent in vitro inhibition.

This study evaluates the virucidal activity and safety of Povidone-iodine in-situ gel formulations against SARS-CoV-2 in vitro and in vivo.

The paper reports two cryo-EM structures of the SARS-CoV-2 spike protein, showing prefusion and postfusion conformations, and discusses their implications for viral entry and immune evasion.

This study shows prohibitin protects human pulmonary microvascular endothelial cells from cigarette smoke extract-induced apoptosis by preserving mitochondrial function and reducing oxidative stress.

The paper identifies myomegalin's role in regulating the Hedgehog pathway by tethering PDE4D3 to the centrosome, showing its impact on medulloblastoma growth.

This study validates CFD simulations of nasal airflow using a 3D-printed model, showing high agreement at lower flow rates but significant deviation at higher flow rates.

This study characterizes the kinetics and stoichiometry of BAP1 and ASXL2 interactions, revealing their structural and functional properties in deubiquitinase activity.

This study shows that Fusobacterium nucleatum binding and invasion of colorectal cancer cells induces IL-8 and CXCL1 secretion, promoting cancer cell migration and immune signaling.

This study develops dihydroartemisinin-loaded magnetic nanoparticles to enhance chemodynamic therapy, showing improved ROS production and efficacy against breast cancer cells, including drug-resistant ones.

The paper determines the cryo-EM structure of HIV-1 Env bound with antibody PG16 Fab, showing it stabilizes a closed conformation similar to SOSIP structures.

This meta-analysis evaluates carbon nanoparticles' effectiveness in improving lymph node detection and protecting parathyroid glands during thyroidectomy, finding increased lymph node harvest and reduced parathyroid complications.

The paper identifies a new genus, Sinoseris, in the sunflower family, based on molecular and morphological analysis of three species, two of which are new to science.

This study shows CCA1 and ATAF2 differentially repress BAS1 and SOB7, which inactivate brassinosteroids, with CCA1 acting as a direct repressor and both regulators interacting.

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.

The paper identifies a potent and selective ROR1-targeting scFv, R11, and determines its structure bound to ROR1, showing its antitumor activity in vitro and in vivo.