Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
D. X. Ji, K. C. Witt, D. I. Kotov, S. R. Margolis, A. Louie, V. Chevee, K. J. Chen, M. Gaidt, H. S. Dhaliwal, A. Y. Lee, S. Nishimura, D. S. Zamboni, I. Kramnik, D. A. Portnoy, K. H. Darwin, R. E. Vance
This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.
bioRxiv · Jan 7, 2020Immunology