Author

D. I. Kotov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:non-human primate· 2

Frequent Co-Authors

R. E. Vance· 4 shared A. Anaya-Sanchez· 2 shared D. Fox· 2 shared D. L. Jaye· 2 shared D. X. Ji· 2 shared K. C. Witt· 2 shared K. H. Darwin· 2 shared O. V. Lee· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

R. E. Vance

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Interleukin-1 receptor antagonist is a conserved factor for exacerbating tuberculosis susceptibility

O. V. Lee, E. Pathak, S. Hernandez-Bazan, D. X. Ji, B. A. Rosa, D. L. Jaye, S. Suliman, M. Mitreva, C. Gabay, R. E. Vance, D. I. Kotov

The paper identifies IL-1 receptor antagonist as a conserved factor limiting Mtb control across mice, non-human primates, and humans.

bioRxiv · Oct 27, 2023 · PreprintImmunology

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

S. Espich, S. Berry, X. Chang, A. Balakhmet, N. T. T. Thuong, R. Dorajoo, C. C. Khor, C. K. Heng, J.-M. Yuan, W.-P. Koh, D. Fox, A. Anaya-Sanchez, L. Tenney, C. J. Chang, R. Baral, , S. A. Stanley

The paper shows ALDH2 deficiency enhances anti-bacterial immunity by increasing aldehyde levels that kill pathogens and boost inflammatory responses.

bioRxiv · Aug 24, 2023 · PreprintMicrobiology

Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils

M. M. Ravesloot-Chavez, E. Van Dis, D. Fox, A. Anaya-Sanchez, S. Espich, X. H. Nguyenla, S. L. Rawal, H. Samani, M. A. Ballinger, H. Thomas, D. I. Kotov, R. Vance, M. Nachman, S. Stanley

The paper identifies a novel neutrophil signature associated with poor tuberculosis control in genetically diverse mice.

bioRxiv · Jun 29, 2023Immunology

Early cellular mechanism of type I interferon-driven susceptibility to tuberculosis

D. I. Kotov, O. V. Lee, S. A. Fattinger, C. Langner, J. V. Guillen, J. M. Peters, A. Moon, E. M. Burd, K. C. Witt, D. B. Stetson, D. L. Jaye, B. D. Bryson, R. E. Vance

This study identifies interstitial macrophages and plasmacytoid dendritic cells as key producers of type I IFN during Mtb infection, showing their role in driving tuberculosis pathogenesis through IFN-driven mechanisms.

bioRxiv · Oct 6, 2022Immunology

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

D. X. Ji, K. C. Witt, D. I. Kotov, S. R. Margolis, A. Louie, V. Chevee, K. J. Chen, M. Gaidt, H. S. Dhaliwal, A. Y. Lee, S. Nishimura, D. S. Zamboni, I. Kramnik, D. A. Portnoy, K. H. Darwin, R. E. Vance

This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.

bioRxiv · Jan 7, 2020Immunology

Chrysalis: A new method for high-throughput histo-cytometry analysis of images and movies.

D. I. Kotov, T. Pengo, J. S. Mitchell, M. J. Gastinger, M. K. Jenkins

Chrysalis automates histo-cytometry analysis of 3D confocal and two-photon images to improve immunology research efficiency.

bioRxiv · Aug 30, 2018Immunology