Author

A. Y. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Bioengineering· 1 Cell Biology· 1 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. E. Vance· 4 shared C. F. Lesser· 2 shared D. A. Portnoy· 2 shared E. A. Turcotte· 2 shared H. M. Morrison· 2 shared J. L. Roncaioli· 2 shared J. S. Cox· 2 shared K. J. Chen· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

R. E. Vance

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

J. L. Roncaioli, J. P. Babirye, R. A. Chavez, F. L. Liu, E. A. Turcotte, A. Y. Lee, C. F. Lesser, R. E. Vance

The paper shows that multiple cell death pathways work together to protect mice from Shigella infection, with some pathways compensating for others when one is removed.

eLife · Jan 16, 2023Peer-reviewedImmunology

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

H. M. Morrison, J. Craft, R. Rivera-Lugo, J. R. Johnson, G. R. Golovkine, C. E. Dodd, E. Van Dis, W. L. Beatty, S. R. Margolis, T. Repasy, I. Shaker, A. Y. Lee, R. E. Vance, S. A. Stanley, N. J. Krogan, , J. S. Cox

bioRxiv · Dec 29, 2022 · PreprintImmunology

Dynamic changes to signal allocation rules in response to variable social environments in house mice

C. H. Miller, M. F. Hillock, J. Yang, B. Carlson-Clarke, K. Haxhillari, A. Y. Lee, M. R. Warden, M. J. Sheehan

This study examines how male house mice adjust their urine marking behavior in response to social environment changes, revealing distinct behavioral strategies based on competitive experience and scent identity.

bioRxiv · Jan 28, 2022 · PreprintEcology

Automated detection of glaucoma with interpretable machine learning using clinical data and multi-modal retinal images

P. Mehta, C. Petersen, J. C. Wen, M. R. Banitt, P. P. Chen, K. D. Bojikian, C. Egan, S.-I. Lee, M. Balazinska, A. Y. Lee, A. Rokem, The UK Biobank Eye and Vision Consortium

This paper develops an interpretable machine learning model for glaucoma detection using clinical data and multi-modal retinal images, achieving high accuracy and identifying both known and novel disease-related features.

American Journal of Ophthalmology · Nov 1, 2021Peer-reviewedBioengineering

NAIP-NLRC4-deficient mice are susceptible to shigellosis

P. S. Mitchell, J. L. Roncaioli, E. A. Turcotte, L. Goers, R. A. Chavez, A. Y. Lee, C. F. Lesser, I. Rauch, R. E. Vance

This study shows that NAIP-NLRC4-deficient mice are susceptible to Shigella infection, mimicking human shigellosis, and reveals that inflammasome-mediated cell death protects against the disease.

bioRxiv · May 16, 2020Microbiology

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

D. X. Ji, K. C. Witt, D. I. Kotov, S. R. Margolis, A. Louie, V. Chevee, K. J. Chen, M. Gaidt, H. S. Dhaliwal, A. Y. Lee, S. Nishimura, D. S. Zamboni, I. Kramnik, D. A. Portnoy, K. H. Darwin, R. E. Vance

This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.

bioRxiv · Jan 7, 2020Immunology

STING controls Herpes Simplex Virus in vivo independent of type I interferon induction

L. H. Yamashiro, S. C. Wilson, H. M. Morrison, V. Karalis, J.-Y. J. Chung, K. J. Chen, H. Bateup, M. L. Szpara, A. Y. Lee, J. S. Cox, R. Vance

This study shows that STING controls HSV-1 infection independently of type I interferon induction, through autophagy and other ancestral functions.

bioRxiv · Dec 12, 2019 · PreprintImmunology

DNA replication-mediated error correction of ectopic CENP-A deposition maintains centromere identity

Y. Nechemia-Arbely, K. H. Miga, O. Shoshani, A. Aslanian, M. A. McMahon, A. Y. Lee, D. Fachinetti, J. R. Yates, B. Ren, D. Cleveland

The paper shows DNA replication removes CENP-A from chromosome arms, preserving centromere identity by maintaining CENP-A at centromeres.

bioRxiv · Sep 27, 2018Cell Biology