H. Shen

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This paper shows epigenetic reprogramming of mesenchymal stem cells into CA-MSCs drives ovarian cancer metastasis through partial MET and WT1/EZH2-mediated mechanisms.

This study reports cryo-EM structures of SIgA complexes, revealing their assembly mechanism and interaction with SpsA, a pneumococcal adhesin.

This study compares the in vitro antifungal activity of SHR8008, a novel tetrazole, to itraconazole and fluconazole against Candida and Cryptococcus species, finding SHR8008 to be significantly more potent.

This study shows BRD2 and SREBP2 work together to increase sigma-2 receptor expression when cells lack cytosolic cholesterol.

This study uses transcriptome analysis to investigate how two herbal extracts in Compound Kushen Injection interact, showing Kushen drives cytotoxicity and Baituling enhances it while activating immune pathways.

This study identifies a non-canonical role for PLK4 in fibroblast cell-type transition and shows its regulation by BRD4 and PDGFR pathways, suggesting PLK4 inhibition as a potential anti-fibrotic intervention.

This study identifies candidate molecular mechanisms of Compound Kushen Injection by analyzing transcriptome changes in cancer cells and linking them to gene expression and pathway alterations.

This study identifies critical compounds in Compound Kushen Injection (CKI) that modulate cell cycle and apoptosis through cytokine signaling pathways.

This study integrates epigenome, exome, and transcriptome data to identify molecular subtypes and homeotic transformation in uterine fibroids.

This study shows that Compound Kushen Injection suppresses cell cycle, DNA repair, and energy metabolism in cancer cells, while its major component oxymatrine has limited effects.

This study compares the antioxidant activity of C3G and C3G liposomes in 2D and 3D cell cultures, finding greater effects in the 3D model.