T. Liang

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2

This study identifies that SARS-CoV-2 spike protein induces cytokine release syndrome by enhancing T cell production of IL-2, which drives inflammatory cytokine release through TLR4 and NF-κB activation.

Experimental study of modified human tendon stem cells to promote graft ligamentation and tendon-bone healing after anterior cruciate ligament reconstruction

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

Effects of carbon to nitrogen ratio (C:N) on water quality and growth performance of Litopenaeus vannamei (Boone, 1931) in the biofloc system with a salinity of 5%

This study examines how different carbon-to-nitrogen ratios affect water quality and shrimp growth in a low-salinity biofloc system, finding that ratios above 16:1 improve performance.

Camel nanobodies broadly neutralize SARS-CoV-2 variants

The paper isolates two camel nanobodies that broadly neutralize SARS-CoV-2 and its variants, showing therapeutic potential in mice.

A novel PD-L1-targeted shark VNAR single domain-based CAR-T strategy for treating breast cancer and liver cancer

This paper develops a PD-L1-targeted shark VNAR-based CAR-T strategy that effectively targets breast and liver cancer cells and reduces tumor metastasis in mice.

Evolution of innate behavioral strategies through competitive population dynamics

This study uses computational models to show how competitive population dynamics shape innate behavioral strategies, finding that organism density affects the existence of optimal strategies and phenotypic diversity.

Fate mapping analysis reveals a novel dermal migratory Langerhans-like cell population

The paper identifies a novel dermal migratory Langerhans-like cell population using fate mapping and single-cell RNA sequencing, showing distinct migration and replenishment characteristics compared to Langerhans cells.

Controlling Cellular Arrangements via Stretched Bioprinting

This paper introduces a bioprinting method that controls cellular orientation through stretching, enabling aligned myofiber formation and effective tissue repair in vivo.

Visualization of individual cell division history in complex tissues

This paper introduces iCOUNT, a tool to track cell division history in human and mouse tissues, and uses scRNA-seq to analyze molecular consequences of division in neural stem cells.

Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries

SARS-CoV-2 proteome microarray for mapping COVID-19 antibody interactions at amino acid resolution

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

For running or burying -- The toe fringe of Phrynocephalus mystaceus is important

This study removes toe fringes from Phrynocephalus mystaceus to test their impact on locomotor and sand-diving performance, finding that toe fringe area significantly affects both.

Risk Factors Associated with Dengue Virus Infection in Guangdong Province: a Community-based Case-control Study

This study identifies risk and protective factors for dengue virus infection in Guangdong Province through a case-control study, finding activities in the park, outdoor sports, and poor indoor daylight quality as risk factors, and air-condition use as protective.

Comparison of antioxidant activity between cyanidin-3-O-glucoside (C3G) liposome and cyanidin-3-O-glucoside (C3G) in 2D and 3D cell cultures

This study compares the antioxidant activity of C3G and C3G liposomes in 2D and 3D cell cultures, finding greater effects in the 3D model.