Author

K. Nargan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:spatial transcriptomics· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. N. Glasgow· 3 shared K. Lumamba· 3 shared T. Naidoo· 3 shared A. J. Steyn· 2 shared A. K. Shalek· 2 shared R. L. Hunter· 2 shared R. Madansein· 2 shared S. Nadeem· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

J. N. Glasgow

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Author profile →

5 papers

Recent·Most cited

Detection of Mycobacterium tuberculosis in human tissue via RNA in situ hybridization

k. Nargan, T. Naidoo, M. Msimang, S. Nadeem, G. Wells, R. L. Hunter, A. Hutton, K. Lumamba, J. N. Glasgow, P. V. Benson, A. J. Steyn

This paper uses RNA in situ hybridization to detect Mycobacterium tuberculosis mRNA in human tissue, identifying Mtb in ZN-negative samples and revealing two distinct Mtb populations.

bioRxiv · Oct 4, 2023 · PreprintMicrobiology

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

H. T. Pacl, K. C. Chinta, V. P. Reddy, S. Nadeem, R. R. Sevalkar, K. Nargan, K. Lumamba, T. Naidoo, J. N. Glasgow, A. Agarwal, A. J. C. Steyn

This study shows that NAD(H) homeostasis in glycolytic myeloid cells is critical for host protection against tuberculosis, with nicotinamide reducing Mtb lung burden.

bioRxiv · Sep 11, 2022 · PreprintMicrobiology

Aggregated Mycobacterium tuberculosis enhances the inflammatory response

A. Sigal, H. Rodel, I. M. Ferreira, C. Ziegler, Y. Ganga, M. Bernstein, S.-H. Hwa, G. Kaplan, G. Lustig, K. Nargan, M. Noursadeghi, A. Steyn, A. K. Shalek

The paper investigates how aggregated Mycobacterium tuberculosis triggers a stronger inflammatory response in macrophages compared to single or multiple non-aggregated bacilli.

bioRxiv · Mar 23, 2021Microbiology

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

bioRxiv · Oct 24, 2020 · PreprintImmunology

3D microarchitecture of the human tuberculous granuloma

G. A. Wells, J. N. Glasgow, K. Nargan, K. Lumamba, R. Madansein, K. Maharaj, R. L. Hunter, T. Naidoo, P. Ramdial, L. Coetzer, S. le Roux, A. du Plessis, A. J. Steyn

This study uses 3D X-ray imaging to reveal complex, branched structures of human tuberculous granulomas, challenging the traditional view of spherical granulomas and suggesting implications for TB treatment strategies.

bioRxiv · Jun 14, 2020 · PreprintMicrobiology