Author

T. Akaike

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

T. Ida· 2 shared A. Mitsune· 1 shared A. Suzuki· 1 shared A. T. Mellis· 1 shared C.-Y. Fu· 1 shared D. D`Andrea· 1 shared E. Kouroussis· 1 shared F. Butter· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

T. Ida

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Glutathione supersulphide regulates T-cell receptor signalling

Y. Sasaki, T. Numakura, M. Yamada, H. Sugiura, T. Matsunaga, T. Ida, M. Morita, A. Suzuki, S. Matsumoto, M. Kawaguchi, T. Kawabe, S. Tayama, Y. Okuyama, T. Takata, K. Inaba, , H. Motohashi

This study shows that glutathione supersulphide regulates T-cell receptor signalling by interacting with the CD3ε chain, affecting TCR activation and inflammation.

bioRxiv · Apr 30, 2024 · PreprintBiochemistry

Sulfite oxidase deficiency causes persulfidation loss and H2S release

C.-Y. Fu, J. B. Kohl, F. Liebsch, D. D`Andrea, M. Mai, A. T. Mellis, E. Kouroussis, T. Ditroi, J. A. Santamaria-Araujo, S. Y. Yeo, H. Endepols, M. Krizkov, V. Kozich, U. Barayeu, T. Akaike, , G. Schwarz

This study shows that SOX deficiency leads to persulfidation loss and increased H2S release, with thiosulfate accumulation and metabolic rewiring in a mouse model.

bioRxiv · Mar 13, 2024 · PreprintBiochemistry

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

Y. Shinkai, Y. Ding, T. Matsui, G. Devitt, M. Akiyama, T.-L. Shen, M. Nishida, T. Ida, T. Akaike, S. Mahajan, J. M. Fukuto, Y. Shigeta, Y. Kumagai

The paper identifies GIF/metallothionein-3 as a sulfane sulfur-binding protein that regulates zinc ion binding and release through a unique C-S-S-Zn structure.

bioRxiv · Oct 19, 2023Biochemistry

Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis

T. Morishima, M. Fakruddin, T. Masuda, Y. Wang, V. A. C. Schoonenberg, F. Butter, Y. Arima, T. Akaike, K. Tomizawa, F. Wei, T. Suda, H. Takizawa

This study shows that Mto1 dysfunction disrupts mitochondrial translation, leading to iron overload and defective erythroid differentiation.

bioRxiv · Mar 5, 2023Cell Biology