A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging.
Sarah R. Ocañas, Walker Hoolehan, Kevin D. Pham, Christian T. Wright, Kyla B. Buettner, Victor A. Ansere, Adeline H. Machalinski, David R. Stanford, Adam M. Kulpa, Hannah Ray, Collyn M. Kellogg, Derek M. Huffman, Arlan G Richardson, Michael B. Stout, Michael J. Beckstead, , Willard M. Freeman
The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.
bioRxiv · Oct 21, 2026 · PreprintNeuroscience