Author

Helen L. Beasley

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 3 Genomics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Assay:whole-genome sequencing· 3 Organism:plant (other)· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:genome assembly· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Sebastian Eves‐van den AkkeriD· 3 shared Alan TraceyiD· 2 shared Eileen DevaneyiD· 2 shared Georgios KoutsovoulosiD· 2 shared James Anthony CottoniD· 2 shared John S. GilleardiD· 2 shared John T. JonesiD· 2 shared Kevin HoweiD· 2 shared

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2018-2024 · peak 1/yr

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3 shared papersGenetics

Sebastian Eves‐van den AkkerORCID

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5 papers

Recent·Most cited

A gene with a thousand alleles: the HYPer-variable effectors of plant-parasitic nematodes

Unnati Sonawala, Helen L. Beasley, Peter Thorpe, Kyriakos Varypatakis, Beatrice Senatori, John T. Jones, Lida Derevnina, Sebastian Eves‐van den Akker

The paper discovers unprecedented allelic variation in HYP effectors of plant-parasitic nematodes, revealing a novel mechanism of programmed genetic variation called HVD-editing.

Cell Genomics · May 29, 2024Peer-reviewedGenetics

The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B.

Shahid Siddique, Zoran S. Radaković, Clarissa Hiltl, Clément Pellegrin, Thomas J. Baum, Helen L. Beasley, Andrew F. Bent, Oliver Chitambo, Divykriti Chopra, Étienne Danchin, Éric Grenier, Samer S. Habash, M. Shamim Hasan, Johannes Helder, Tarek Hewezi, , Sebastian Eves‐van den Akker

The paper identifies susceptibility genes involved in trans-kingdom vitamin B synthesis between a plant-parasitic nematode and its host, revealing a horizontal gene transfer critical for parasitism.

Nature Communications · Oct 19, 2022Peer-reviewedGenetics

Towards genetic modification of plant-parasitic nematodes: delivery of macromolecules to adults and expression of exogenous mRNA in second stage juveniles.

Olaf Prosper Kranse, Helen L. Beasley, Sally Adams, André Pires‐daSilva, Christopher A. Bell, Catherine J. Lilley, Peter E. Urwin, David McK. Bird, Eric Alexander Miska, Geert Smant, Godelieve Gheysen, John T. Jones, Mark Viney, Pierre Abad, Thomas R. Maier, , Sebastian Eves‐van den Akker

This paper develops methods for delivering macromolecules and expressing exogenous mRNA in plant-parasitic nematodes, advancing functional genetic tools for these pests.

G3 Genes Genomes Genetics · Feb 1, 2021Peer-reviewedGenetics

Extensive genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

Stephen R. Doyle, Alan Tracey, Roz Laing, Nancy E. Holroyd, David J. Bartley, Wojtek Bazant, Helen L. Beasley, Robin N. Beech, Collette Britton, Karen L. Brooks, Umer Naveed Chaudhry, Kirsty Maitland, Axel Martinelli, Jennifer D. Noonan, Michael Paulini, , James Anthony Cotton

The paper presents a high-quality, chromosome-scale genome assembly of Haemonchus contortus using long-read sequencing, revealing genetic diversity and transcriptional regulation.

Communications Biology · Nov 9, 2020Peer-reviewedGenomics

Comparative genomics of the major parasitic worms

Avril Coghlan, James Anthony Cotton, Nancy E. Holroyd, Adam James Reid, Diogo M. Ribeiro, Eleanor Stanley, Helen L. Beasley, Hayley M. Bennett, Stephen R. Doyle, Daria Gordon, Bhavana Harsha, Thomas Huckvale, Jane Lomax, Gabriel Rinaldi, Myriam Shafie, , Lian-Chen Wang

This paper compares genomes of 81 nematode and platyhelminth species to identify gene families related to parasitism and prioritize new drug targets.

Nature Genetics · Oct 29, 2018Peer-reviewedGenomics