David J. Bartley

A comparative analysis of liver tissue and novel primary organoid cultures from ruminants reveals species-specific immune architecture and metabolic specialization

This study develops and characterizes bovine and ovine liver organoids, revealing species-specific differences in immune architecture and metabolic specialization.

GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research

This paper develops a metapopulation model for cattle gastrointestinal nematodes to evaluate biosecurity measures and their impact on anthelmintic resistance.

Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta

The paper generates a chromosome-scale genome assembly for Teladorsagia circumcincta and identifies genetic loci associated with drug resistance to improve anthelmintic resistance diagnostics.

Optimisation of single-nuclei isolation and RNA sequencing of parasitic nematodes

This paper optimizes single-nuclei isolation and RNA sequencing for parasitic nematodes, improving yield and RNA quality across life stages and sexes.

Genomic landscape of drug response reveals novel mediators of anthelmintic resistance

The paper maps resistance loci for three anthelmintic classes in a parasitic nematode, identifies novel alleles for benzimidazoles and levamisole, and implicates cky-1 in ivermectin resistance.

Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode

This paper identifies gene expression changes associated with ivermectin resistance in parasitic nematodes through genetic crosses and RNA-seq, revealing upregulation of specific genes linked to neuronal plasticity and chloride homeostasis.

Extensive genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

The paper presents a high-quality, chromosome-scale genome assembly of Haemonchus contortus using long-read sequencing, revealing genetic diversity and transcriptional regulation.

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

The paper identifies a single major QTL on chromosome V associated with ivermectin resistance in Haemonchus contortus through genome-wide analysis of genetic crosses.

Development of high throughput methods for the analysis of anthelmintic resistance allele frequencies in field populations of gastrointestinal nematodes.

The paper develops a high-throughput method to determine anthelmintic resistance allele frequencies in gastrointestinal nematodes using Illumina Mi-seq sequencing.

A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry

This paper constructs a genetic map of Haemonchus contortus using whole-genome resequencing, revealing recombination patterns and reproductive traits like polyandry and polyploidy.