Author

Hirotaka Ishihara

Kyoto Prefectural University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Kento OhbayashiiD· 2 shared Toshihiko YadaiD· 2 shared Yusaku IwasakiiD· 2 shared Aki Nagao· 1 shared Chikara AbeiD· 1 shared Daniel J. DruckeriD· 1 shared Kengo Iba· 1 shared Mamoru TanidaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

Kento OhbayashiORCID

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2 papers

Recent·Most cited

Gut-derived GLP-1 released by rare sugar D-allulose cooperates with insulin to activate left-sided vagal afferents and enhance insulin sensitivity

Kento Ohbayashi, Mamoru Tanida, Chikara Abe, Hirotaka Ishihara, Wataru Omi, Naoto Kubota, Daniel J. Drucker, Toshihiko Yada, Yusaku Iwasaki

This paper shows that D-allulose-induced GLP-1 enhances insulin action via left-sided vagal afferents, improving glucose tolerance more effectively than GLP-1 receptor agonists in mice.

Diabetes · May 1, 2026Peer-reviewedPhysiology

Exacerbation of sucrose-induced visceral obesity and glucose intolerance by ovariectomy and its GLP-1-dependent amelioration by the rare sugar D-allulose

Kengo Iba, MIharu Kyo, Hirotaka Ishihara, Aki Nagao, Misaki Kawabe, Kento Ohbayashi, Toshihiko Yada, Yusaku Iwasaki

This study shows that D-allulose reduces visceral obesity and glucose intolerance in ovariectomized mice, with effects dependent on GLP-1.

bioRxiv · Jan 7, 2026 · PreprintPhysiology