Gut-derived GLP-1 released by rare sugar D-allulose cooperates with insulin to activate left-sided vagal afferents and enhance insulin sensitivity
Kento Ohbayashi, Mamoru Tanida, Chikara Abe, Hirotaka Ishihara, Wataru Omi, Naoto Kubota, Daniel J. Drucker, Toshihiko Yada, Yusaku Iwasaki
This paper shows that D-allulose-induced GLP-1 enhances insulin action via left-sided vagal afferents, improving glucose tolerance more effectively than GLP-1 receptor agonists in mice.
Diabetes · May 1, 2026Peer-reviewedPhysiology