Author

Hsin-Lan Wen

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Li‐Huei TsaiiD· 2 shared Liwang Liu· 2 shared Oyku CeritiD· 2 shared Abigail K. R. Lytton‐JeaniD· 1 shared Adele Bubnys· 1 shared Aine Ni Scannail· 1 shared Alan Y. L. JiangiD· 1 shared Alice E. StantoniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Li‐Huei TsaiORCID

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2 papers

Recent·Most cited

Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

Alice E. Stanton, Adele Bubnys, Emre Agbas, Benjamin T. James, Dong Shin Park, Alan Y. L. Jiang, Rebecca L. Pinals, Liwang Liu, Nhat Truong, Anjanet R. Loon, Colin Staab, Oyku Cerit, Hsin-Lan Wen, David V. Mankus, Margaret E. Bisher, , Li‐Huei Tsai

The paper constructs a 3D human brain model integrating multiple cell types to study Alzheimer's Disease mechanisms linked to APOE4.

Proceedings of the National Academy of Sciences · Oct 17, 2025Peer-reviewedNeuroscience

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna Katrina von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Julia Maeve Bonner, Li‐Huei Tsai

This study shows that APOE4 in microglia causes lipid accumulation, impairing their ability to monitor neuronal activity and leading to disrupted neuronal network function.

Cell stem cell · Aug 1, 2022Peer-reviewedNeuroscience