Author

C.-L. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. Lippincott-Schwartz· 3 shared A. Shirinifard· 2 shared C. S. Xu· 2 shared D. R. Stabley· 2 shared G. Shtengel· 2 shared H. A. Pasolli· 2 shared H. F. Hess· 2 shared M. Freeman· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

J. Lippincott-Schwartz

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6 papers

Recent·Most cited

Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

S.-W. Huang, Y.-G. Lai, H.-T. Liao, C.-L. Chang, R.-Y. Ma, Y.-H. Chen, Y.-H. Liou, Z.-Q. Wu, Y.-C. Wu, K.-J. Liu, Y.-T. Huang, J.-L. Yang, M.-S. Dai, N.-S. Liao

This study shows that autologous NK cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases in a mouse model and a clinical trial.

bioRxiv · May 3, 2024Immunology

Science Education for the Youth (SEFTY): A Neuroscience Outreach Program for High School Students in Southern Nevada During the COVID-19 Pandemic

N. Ghani, H. Baker, A. Huntsinger, T. Chen, T. D. Familara, J. Y. Itorralba, F. Vanderford, X. Zhuang, C.-L. Chang, V. Vo, E. Oh

The SEFTY program provided neuroscience-based experiential learning to high school students during the pandemic, improving science proficiency by 20.3%.

bioRxiv · Feb 2, 2024Scientific Communication & Education

A fluorogenic complementation tool kit for interrogating lipid droplet-organelle interaction

X. Li, R. Gamuyao, M.-L. Wu, W. J. Cho, N. B. Kurtz, S. V. King, R. A. Petersen, D. R. Stabley, C. Lindow, L. Climer, A. Shirinifard, F. Ferrara, R. E. Throm, C. G. Robinson, A. Carisey, , C.-L. Chang

This paper introduces FABCON, a tool for detecting lipid droplet-organelle contact sites in living cells, showing their dynamic behavior under different metabolic conditions.

bioRxiv · Nov 29, 2023Cell Biology

Vacuole phase-partitioning boosts mitochondria activity and cell lifespan through an inter-organelle lipid pipeline

A. Y. Seo, F. Sarkleti, I. Budin, C.-L. Chang, C. R. King, S.-D. Kohlwein, P. Sengupta, J. Lippincott-Schwartz

The paper identifies a lipid trafficking pathway between yeast vacuoles and mitochondria that enhances mitochondrial activity and cell lifespan under glucose starvation.

bioRxiv · Apr 11, 2021 · PreprintCell Biology

Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells

D. P. Hoffman, G. Shtengel, C. S. Xu, K. R. Campbell, M. Freeman, L. Wang, D. E. Milkie, H. A. Pasolli, N. Iyer, J. A. Bogovic, D. R. Stabley, A. Shirinifard, S. Pang, D. Peale, K. Schaefer, , H. F. Hess

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

bioRxiv · Sep 18, 2019Cell Biology

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

C.-L. Chang, A. V. Weigel, M. S. Ioannou, H. A. Pasolli, C. S. Xu, D. R. Peale, G. Shtengel, M. Freeman, H. F. Hess, C. Blackstone, J. Lippincott-Schwartz

This study identifies Spastin's role in tethering lipid droplets to peroxisomes and facilitating fatty acid trafficking via ESCRT-III proteins.

bioRxiv · Feb 14, 2019Cell Biology